Molecular mechanisms directing PRC2 recruitment and H3K27 methylation
A Laugesen, JW Højfeldt, K Helin - Molecular cell, 2019 - cell.com
The polycomb repressive complex 2 (PRC2) is a chromatin-associated methyltransferase
catalyzing mono-, di-, and trimethylation of lysine 27 on histone H3 (H3K27). This activity is …
catalyzing mono-, di-, and trimethylation of lysine 27 on histone H3 (H3K27). This activity is …
PRC2 is high maintenance
As the process that silences gene expression ensues during development, the stage is set
for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene …
for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene …
The complexity of PRC2 subcomplexes
Polycomb repressive complex 2 (PRC2) is a multisubunit protein complex essential for the
development of multicellular organisms. Recruitment of PRC2 to target genes, followed by …
development of multicellular organisms. Recruitment of PRC2 to target genes, followed by …
Regulation of gene transcription by Polycomb proteins
S Aranda, G Mas, L Di Croce - Science advances, 2015 - science.org
The Polycomb group (PcG) of proteins defines a subset of factors that physically associate
and function to maintain the positional identity of cells from the embryo to adult stages. PcG …
and function to maintain the positional identity of cells from the embryo to adult stages. PcG …
Polycomb gene silencing mechanisms: PRC2 chromatin targeting, H3K27me3'readout', and phase separation-based compaction
Modulation of chromatin structure and/or modification by Polycomb repressive complexes
(PRCs) provides an important means to partition the genome into functionally distinct …
(PRCs) provides an important means to partition the genome into functionally distinct …
Going beyond Polycomb: EZH2 functions in prostate cancer
Abstract The Polycomb group (PcG) protein Enhancer of Zeste Homolog 2 (EZH2) is one of
the three core subunits of the Polycomb Repressive Complex 2 (PRC2). It harbors histone …
the three core subunits of the Polycomb Repressive Complex 2 (PRC2). It harbors histone …
Mechanisms regulating PRC2 recruitment and enzymatic activity
D Holoch, R Margueron - Trends in biochemical sciences, 2017 - cell.com
Polycomb repressive complex 2 (PRC2) and its histone H3 lysine-27 methylation activity are
crucial for multicellular development by virtue of their role in maintaining transcriptional …
crucial for multicellular development by virtue of their role in maintaining transcriptional …
Non-core subunits of the PRC2 complex are collectively required for its target-site specificity
JW Højfeldt, L Hedehus, A Laugesen, T Tatar, L Wiehle… - Molecular cell, 2019 - cell.com
The Polycomb repressive complex 2 (PRC2) catalyzes H3K27 methylation across the
genome, which impacts transcriptional regulation and is critical for establishment of cell …
genome, which impacts transcriptional regulation and is critical for establishment of cell …
Dynamic competition of polycomb and trithorax in transcriptional programming
Predicting regulatory potential from primary DNA sequences or transcription factor binding
patterns is not possible. However, the annotation of the genome by chromatin proteins …
patterns is not possible. However, the annotation of the genome by chromatin proteins …
PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing
PALI1 is a newly identified accessory protein of the Polycomb repressive complex 2 (PRC2)
that catalyzes H3K27 methylation. However, the roles of PALI1 in cancer are yet to be …
that catalyzes H3K27 methylation. However, the roles of PALI1 in cancer are yet to be …