Hepcidin, the iron-regulatory hormone, determines plasma iron concentrations and total
body iron content. Hepcidin, secreted by hepatocytes, functions by controlling the activity of …

An abundant metal in the human body, iron is essential for key biological pathways
including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound …

Despite its abundance in the environment, iron is poorly bioavailable and subject to strict
conservation and internal recycling by most organisms. In vertebrates, the stability of iron …

Iron is biologically essential, but also potentially toxic; as such it is tightly controlled at cell
and systemic levels to prevent both deficiency and overload. Iron regulatory proteins post …

Oncogenic mutations in KRAS drive common metabolic programmes that facilitate tumour
survival, growth and immune evasion in colorectal carcinoma, non-small-cell lung cancer …

Iron is a transition metal and essential constituent of almost all living cells and organisms. As
component of various metalloproteins it is involved in critical biochemical processes such as …

Ferroptosis is a new form of regulated cell death (RCD) driven by iron-dependent lipid
peroxidation, which is morphologically and mechanistically distinct from other forms of RCD …

The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also
harbors a large and diverse microbial population collectively called the gut microbiome …

Iron is essential in many physiological processes, including DNA metabolism, oxygen
transport, and cellular energy generation. Deregulated iron metabolism, which results in iron …

Iron is a central micronutrient needed by all living organisms. Competition for iron in the
intestinal tract is essential for the maintenance of indigenous microbial populations and for …