Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is overexpressed and
activated in many cancer types. FAK regulates diverse cellular processes, including growth …

Integrins are transmembrane receptors that possess distinct ligand-binding specificities in
the extracellular domain and signaling properties in the cytoplasmic domain. While most …

Focal adhesion kinase (FAK), a nonreceptor cytoplasmic tyrosine kinase, is a vital
participant in primary cellular functions, such as proliferation, survival, migration, and …

Breast cancer (BC) involves complex signaling networks characterized by extensive cross-
communication and feedback loops between and within multiple signaling cascades. Many …

Background Over the last two decades, tumor-derived RNA expression signatures have
been developed for the two most commonly diagnosed tumors worldwide, namely prostate …

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase over-expressed and
activated in both adult and pediatric cancers, where it plays important roles in the regulation …

Over the last five decades, breast density has been associated with increased risk of
developing breast cancer. Mammographically dense breasts are considered those …

The current study describes the synthesis, physicochemical characterization and cytotoxicity
evaluation of a new series of pyrrole derivatives in order to identify new bioactive molecules …

Triple-negative breast cancer (TNBC) is the most aggressive molecular subtype of breast
cancer. Curcumol, as a natural small molecule compound, has potential anti-breast cancer …

Breast cancer is the most common invasive malignancy among women worldwide and
constitutes a complex and heterogeneous disease. Interest has recently grown in the role of …