Uncovering the cis-regulatory code that governs when and how much each gene is
transcribed in a given genome and cellular state remains a central goal of biology. Here, we …

Physical access to DNA is a highly dynamic property of chromatin that plays an essential
role in establishing and maintaining cellular identity. The organization of accessible …

Abstract ChIP-Atlas (https://chip-atlas. org) is a web service providing both GUI-and API-
based data-mining tools to reveal the architecture of the transcription regulatory landscape …

The switch/sucrose non-fermentable (SWI/SNF) complex has a crucial role in chromatin
remodelling and is altered in over 20% of cancers,. Here we developed a proteolysis …

The roles and regulatory mechanisms of ferroptosis (a non-apoptotic form of cell death) in
cancer remain unclear. The tumour suppressor BRCA1-associated protein 1 (BAP1) …

Cleavage under targets and release using nuclease (CUT&RUN) is an epigenomic profiling
strategy in which antibody-targeted controlled cleavage by micrococcal nuclease releases …

Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …

Transcriptional regulation underlies many of the growth and developmental processes that
shape plants as well as their adaptation to their environment. Key to transcriptional control …

Transcription factors (TFs) that bind common DNA motifs in vitro occupy distinct sets of
promoters in vivo, raising the question of how binding specificity is achieved. TFs are …

Rheumatoid arthritis (RA) is considered a chronic systemic, multi-factorial, inflammatory, and
progressive autoimmune disease affecting many people worldwide. While patients show …