Opioid-induced respiratory depression (OIRD) represents the primary cause of death
associated with therapeutic and recreational opioid use. Within the United States, the rate of …

Scientific interest in the brain and body interactions has been surging in recent years. One
fundamental yet underexplored aspect of brain and body interactions is the link between the …

Breathing is a vital behavior that ensures both the adequate supply of oxygen and the
elimination of CO 2, and it is influenced by many factors. Despite that most of the studies in …

Respiratory depression is the proximal cause of death in opioid overdose, yet the
mechanisms underlying this potentially fatal outcome are not well understood. The goal of …

An interoceptive homeostatic system monitors levels of CO2/H+ and provides a
proportionate drive to respiratory control networks that adjust lung ventilation to maintain …

Congenital central hypoventilation syndrome (CCHS) is a genetic disorder of
neurodevelopment, with an autosomal dominant transmission, caused by heterozygous …

The role of the lateral geniculate nucleus (LGN) in vision has been extensively studied, yet
its extraretinal capacities are still being investigated, including its role in arousal from sleep …

Ketamine (KET) and isoflurane (ISO) are two widely used general anesthetics, yet their
distinct and shared neurophysiological mechanisms remain elusive. In this study, we …

The lateral parafacial region (pFL; which encompasses the parafacial respiratory group,
pFRG) is a conditional oscillator that drives active expiration during periods of high …

The distribution of locomotor-activated neurons in the brainstem of the cat was studied by c-
Fos immunohistochemistry in combination with antibody-based cellular phenotyping …