The calcium-based intracellular signalling system is used ubiquitously to couple
extracellular stimuli to their characteristic intracellular responses. It is becoming clear from …

Allosteric drug development holds promise for delivering medicines that are more selective
and less toxic than those that target orthosteric sites. To date, the discovery of allosteric …

Abstract Since 1992 PredictProtein (https://predictprotein. org) is a one-stop online resource
for protein sequence analysis with its main site hosted at the Luxembourg Centre for …

The degree of evolutionary conservation of an amino acid in a protein or a nucleic acid in
DNA/RNA reflects a balance between its natural tendency to mutate and the overall need to …

Tuft cells are a rare chemosensory lineage that coordinates immune and neural responses
to foreign pathogens in mucosal tissues. Recent studies have also revealed tuft-cell-like …

PredictProtein is a meta-service for sequence analysis that has been predicting structural
and functional features of proteins since 1992. Queried with a protein sequence it returns …

Muscarinic M1–M5 acetylcholine receptors are G-protein-coupled receptors that regulate
many vital functions of the central and peripheral nervous systems. In particular, the M1 and …

Here, we describe the discovery of a naturally occurring human antibody (Ab), FluA-20, that
recognizes a new site of vulnerability on the hemagglutinin (HA) head domain and reacts …

Cationic polyamines such as spermidine and spermine are critical in all forms of life, as they
regulate the function of biological macromolecules. Intracellular polyamine metabolism is …

Interferon-stimulated gene product 15 (ISG15) is a key component of host responses to
microbial infection. Despite having been known for four decades, grasping the functions and …