The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975
was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered …

The retromer complex is a vital element of the endosomal protein sorting machinery that is
conserved across all eukaryotes. Retromer is most closely associated with the endosome-to …

Retromer is a multi-protein complex that recycles transmembrane cargo from endosomes to
the trans-Golgi network and the plasma membrane. Defects in retromer impair various …

Following endocytosis into the endosomal network, integral membrane proteins undergo
sorting for lysosomal degradation or are retrieved and recycled back to the cell surface. Here …

VPS35, a major component of the retromer complex, is important for endosome-to-Golgi
retrieval of membrane proteins. Although implicated in Alzheimer's disease (AD), how …

We have developed a method for rapidly inactivating proteins with rapamycin-induced
heterodimerization. Cells were stably transfected with siRNA-resistant, FKBP-tagged …

Sortilin is a type-1 receptor expressed in neurons of the central and peripheral nervous
systems. Initially considered a rather peculiar receptor resembling an intracellular sorting …

The retromer complex is a conserved endosomal protein sorting complex that sorts
membrane proteins into nascent endosomal tubules. The recognition of membrane proteins …

sorLA is a sorting receptor for amyloid precursor protein (APP) genetically linked to
Alzheimer's disease (AD). Retromer, an adaptor complex in the endosome-to-Golgi retrieval …

Sortilin is a post-Golgi trafficking receptor homologous to the yeast vacuolar protein sorting
receptor 10 (VPS10). The VPS10 motif on sortilin is a 10-bladed β-propeller structure …