Animal models are essential tools for addressing fundamental scientific questions about
skeletal diseases and for the development of new therapeutic approaches. Traditionally …

During vertebrate craniofacial development, neural crest cells (NCCs) contribute much of the
cartilage, bone and connective tissue that make up the developing head. Although the initial …

The broad spectrum herbicide glyphosate is widely used in agriculture worldwide. There has
been ongoing controversy regarding the possible adverse effects of glyphosate on the …

Using a descanned, laser-induced guide star and direct wavefront sensing, we demonstrate
adaptive correction of complex optical aberrations at high numerical aperture (NA) and a 14 …

Since its debut in the biomedical research fields in 1981, zebrafish have been used as a
vertebrate model organism in more than 40,000 biomedical research studies. Especially …

The formation of the face and skull involves a complex series of developmental events
mediated by cells derived from the neural crest, endoderm, mesoderm, and ectoderm …

The vertebrate planar cell polarity (PCP) pathway has previously been found to control
polarized cell behaviors rather than cell fate. We report here that disruption of Xenopus …

Osteoporosis is metabolic bone disease caused by an altered balance between bone
anabolism and catabolism. This dysregulated balance is responsible for fragile bones that …

In the vertebrate embryo, the neural crest forms transiently in the dorsal neural primordium to
yield migratory cells that will invade nearly all tissues and later, will differentiate into bones …

Disruption of signaling pathways such as those mediated by sonic hedgehog (Shh) or
platelet-derived growth factor (Pdgf) causes craniofacial abnormalities, including cleft palate …