Purpose To systematically review randomized controlled trials to compare clinical outcomes
of microfracture (MFx) versus third-generation autologous chondrocyte implantation (ACI) for …

Background The regeneration and repair of articular cartilage remains a major challenge for
clinicians and scientists due to the poor intrinsic healing of this tissue. Since cartilage …

Articular cartilage consists of hyaline cartilage, is a major constituent of the human
musculoskeletal system and has critical functions in frictionless joint movement and articular …

Objective Biologics are increasingly used for cartilage repair and osteoarthritis (OA)
treatment. This study aimed to provide an overview of the clinical trials conducted on this …

Articular cartilage defects significantly compromise the quality of life in the global population.
Although many strategies are needed to repair articular cartilage, including microfracture …

Objective The objective of this study was to evaluate the best available mid-to long-term
evidence of surgical procedures for the treatment of localized full-thickness cartilage defects …

Pain-associated knee joint disorders are common in daily life. Practically, knee pain should
be divided into the origin from the isolated tibiofemoral (TF), isolated patellofemoral (PF) …

Injured articular cartilage is a leading cause for osteoarthritis. We recently discovered that
endogenous stem/progenitor cells not only reside in the superficial zone of mouse articular …

Articular cartilage is composed of superficial, medial, and deep zones, which endow the
tissue with biphasic mechanical properties to withstand shearing force and compressional …

BACKGROUND Multitudinous advancements have been made to the traditional
microfracture (MFx) technique, which have involved delivery of various acellular 2 nd …