Regulatory T cells (Tregs) are abundant in tumor tissues, raising a question of whether
immunosuppressive tumor-infiltrating Tregs (TI-Tregs) can be selectively depleted or …

Tumors evade immune-mediated recognition through multiple mechanisms of immune
escape. On chronic tumor antigen exposure, T cells become dysfunctional/exhausted and …

Over the past decade, immune checkpoint inhibitors (ICIs) have emerged as a revolutionary
cancer treatment modality, offering long-lasting responses and survival benefits for a …

T cells are key elements of cancer immunotherapy but certain fundamental properties, such
as the development and migration of T cells within tumours, remain unknown. The enormous …

Co-inhibitory receptors, such as CTLA-4 and PD-1, have an important role in regulating T
cell responses and have proven to be effective targets in the setting of chronic diseases …

Gut dysbiosis might underlie the pathogenesis of type 1 diabetes. In mice of the non-obese
diabetic (NOD) strain, we found that key features of disease correlated inversely with blood …

Background DNA methylation levels change with age. Recent studies have identified
biomarkers of chronological age based on DNA methylation levels. It is not yet known …

T cell Ig and ITIM domain (TIGIT) is an inhibitory receptor expressed by activated T cells,
Tregs, and NK cells. Here, we determined that TIGIT is upregulated on tumor antigen …

Unresolved low grade systemic inflammation represents the underlying pathological
mechanism driving immune and metabolic pathways involved in autoimmune diseases …

The nature and extent of immune cell infiltration into solid tumours are key determinants of
therapeutic response. Here, using a DNA methylation-based approach to tumour cell …