Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that
expand during cancer, inflammation and infection, and that have a remarkable ability to …

Abstract l-Arginine is an essential amino acid for birds and young mammals, and it is a
conditionally essential amino acid for adult mammals, as it is important in situations in which …

Suppression of immune responses is necessary to limit damage to host tissue during
inflammation, but it can be detrimental in specific immune responses, such as sepsis and …

Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of cells that play a
critical role in tumor associated immune suppression. In an attempt to identify a specific …

Abstract Antigen-specific CD8+ T-cell tolerance, induced by myeloid-derived suppressor
cells (MDSCs), is one of the main mechanisms of tumor escape. Using in vivo models, we …

Tumors require a constant influx of myelomonocytic cells to support the angiogenesis and
stroma remodeling needed for their growth. This is mediated by tumor-derived factors, which …

The topic of immunity to fungal infections is of interest to a wide range of disciplines, from
microbiology to immunology. It is of particular interest in terms of therapy of HIV-infected …

Emerging evidence indicates that the Achilles' heel of cancer immunotherapies is often the
complex interplay of tumor‐derived factors and deviant host properties, which involve a wide …

Neutrophils (PMN) have been described as critical effector cells in the host's antibacterial
innate immunities. However, the classification of murine PMNs remains unclear. Here, we …

Leucocytes form the principal cellular components of immunity and inflammation, existing as
multiple subsets defined by distinct phenotypic and functional profiles. To date, this has most …