ETS-related gene (ERG) is a member of the E-26 transformation-specific (ETS) family of
transcription factors with roles in development that include vasculogenesis, angiogenesis …

More than 95% of the 20,000 to 25,000 transcribed human genes undergo alternative RNA
splicing, which increases the diversity of the proteome. Isoforms derived from the same gene …

Importance Overdiagnosis and overtreatment of indolent prostate cancer (PCA) is a serious
health issue in most developed countries. There is an unmet clinical need for noninvasive …

Abstract Purpose: Serum PSA (sPSA) testing has led to the identification of patients with
indolent prostate cancer, and inevitably overtreatment has become a concern. Progensa …

Background: New screening methods that can add predictive diagnostic value for
aggressive (high-grade, Gleason score⩾ 7) prostate cancer (PCa) are needed to reduce …

We sought to define the landscape of alternative pre-mRNA splicing in prostate cancers and
the relationship of exon choice to known cancer driver alterations. To do so, we compiled a …

Background Initial prostate biopsy often fails to identify prostate cancer resulting in patient
anxiety, especially when clinical features such as prostate specific antigen (PSA) remain …

BACKGROUND There is controversy in the literature on the role of the fusion TMPRSS2‐
ERG in the pathogenesis and progression of prostate cancer. The quantitative differences in …

Abstract Changes in mRNA splice patterns have been associated with key pathological
mechanisms in prostate cancer progression. The androgen receptor (abbreviated AR) …

Androgens are steroid hormones governing the male reproductive development and
function. As such, androgens and the key mediator of their effects, androgen receptor (AR) …