Over the past decade, single-cell genomics technologies have allowed scalable profiling of
cell-type-specific features, which has substantially increased our ability to study cellular …

Genome-wide association studies (GWAS) have linked hundreds of thousands of sequence
variants in the human genome to common traits and diseases. However, translating this …

Abstract Oxidative modification of 5-methylcytosine (5mC) by ten-eleven translocation (TET)
DNA dioxygenases generates 5-hydroxymethylcytosine (5hmC), the most abundant form of …

Abstract Dynamic 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)
modifications to DNA regulate gene expression in a cell-type-specific manner and are …

Single-cell omics technologies have revolutionized molecular profiling by providing high-
resolution insights into cellular heterogeneity and complexity. Traditional bulk omics …

The genome-wide DNA methylation profile, or DNA methylome, is a critical component of the
overall epigenomic landscape that modulates gene activities and cell fate. Single-cell DNA …

Epigenetics is the study of inherited variations in gene expression that do not involve
changes to DNA sequences. Over 200 unique cell types in a human adult have a nearly …

Lymphoid neoplasms represent a heterogeneous group of disease entities and subtypes
with markedly different molecular and clinical features. Beyond genetic alterations, lymphoid …

Hepatoblastomas (HB) display heterogeneous cellular phenotypes that influence the clinical
outcome, but the underlying mechanisms are poorly understood. Here, we use a single-cell …

DNA methylation is a key component of the mammalian epigenome, playing a regulatory
role in development, disease, and other processes. Robust, high-throughput single-cell DNA …