Materials that respond to endogenous stimuli are being leveraged to enhance
spatiotemporal control in a range of biomedical applications from drug delivery to diagnostic …

Nanocarriers providing spatiotemporal control of drug release contribute to reducing toxicity
and improving therapeutic efficacy of a drug. On the other hand, nanocarriers face unique …

Self-assembled nanostructures of amphiphilic and double hydrophilic block copolymers
have been increasingly utilized as potent polymeric nanocarriers of therapeutic drugs …

Stimulus responsive nanogels are polymeric nanoparticles which are capable of responding
to external stimuli by changing their physico-chemical properties, such as volume, water …

We highlight recent developments in hydrogel materials with biological responsiveness built
in. These 'smart'biomaterials change properties in response to selective biological …

Enzyme-responsive materials (ERMs) are a new class of smart materials that undergo
macroscopic transitions when triggered by selective catalytic actions of enzymes. The use of …

Polymer-based nanogel formulations offer features attractive for drug delivery, including
ease of synthesis, controllable swelling and viscoelasticity as well as drug loading and …

Reactive oxygen species (ROS) play key roles in many physiological processes, such as
cell signaling and host innate immunity. However, when they are overproduced, ROS may …

Reactive Oxygen Species (ROS) are quintessential inflammatory compounds with oxidizing
behavior. We have successfully developed a micellar system with responsiveness at the …

Prodrugs are designed to improve pharmaceutical properties of potent compounds and
represent a central approach in drug development. The success of the prodrug strategy …