Prognostic and predictive molecular markers in cholangiocarcinoma

S Pavicevic, S Reichelt, D Uluk, I Lurje, C Engelmann… - Cancers, 2022 - mdpi.com
Simple Summary Cholangiocarcinoma (CCA) is a heterogenous and aggressive
malignancy of the intra-and extrahepatic biliary tract, marked by a steeply rising incidence …

[HTML][HTML] Surgical therapy for perihilar cholangiocarcinoma: state of the art

LE Nooijen, RJ Swijnenburg, HJ Klümpen, J Verheij… - Visceral …, 2021 - karger.com
Background: Surgical therapy still offers the only chance of long-term survival for patients
with perihilar cholangiocarcinoma (pCCA). The aim of this narrative review is to summarize …

Genetic polymorphisms in interleukin-1β (rs1143634) and interleukin-8 (rs4073) are associated with survival after resection of intrahepatic cholangiocarcinoma

I Lurje, NT Gaisa, E Dahl, R Knüchel, P Strnad… - Scientific Reports, 2023 - nature.com
Intrahepatic cholangiocarcinoma (iCCA) is a rare, understudied primary hepatic malignancy
with dismal outcomes. Aiming to identify prognostically relevant single-nucleotide …

Genetic variant of CXCR1 (rs2234671) associates with clinical outcome in perihilar cholangiocarcinoma

I Lurje, Z Czigany, J Bednarsch, NT Gaisa, E Dahl… - Liver Cancer, 2022 - karger.com
Background: Perihilar cholangiocarcinoma (pCCA) is a rare primary liver malignancy. Even
in patients amenable to surgery, outcomes are often dismal. Here, we aimed to identify …

Bacterial bile duct colonization in perihilar cholangiocarcinoma and its clinical significance

J Bednarsch, Z Czigany, LR Heij, T Luedde… - Scientific Reports, 2021 - nature.com
Abdominal infections including cholangitis represent a major problem in patients with
perihilar cholangiocarcinoma (pCCA). Thus, we investigated bacterial colonization of the …

Textbook outcome after major hepatectomy for perihilar cholangiocarcinoma—definitions and influencing factors

C Benzing, LM Haiden, F Krenzien, A Mieg… - … Archives of Surgery, 2022 - Springer
Purpose The concept of “textbook outcome”(TO) as composite quality measure depicting the
ideal surgical has not yet been defined for patients undergoing major hepatectomy (MH) for …

[HTML][HTML] Nerve fibers in the tumor microenvironment as a novel biomarker for oncological outcome in patients undergoing surgery for perihilar cholangiocarcinoma

J Bednarsch, J Kather, X Tan, S Sivakumar, C Cacchi… - Liver cancer, 2021 - karger.com
Introduction: Perihilar cholangiocarcinoma (pCCA) is a biliary tract cancer with a dismal
prognosis, with surgery being the only chance of cure. A characteristic aggressive biological …

Left-side vs. right-side hepatectomy for hilar cholangiocarcinoma: a meta-analysis

W Wu, Q Cheng, J Chen, D Chen, X Feng… - World journal of surgical …, 2021 - Springer
Goals We aim to draw a conclusion which type of hepatectomy could be the priority for hilar
cholangiocarcinoma patients. Background Surgery is established as only potentially curative …

Higher postoperative mortality and inferior survival after right-sided liver resection for perihilar cholangiocarcinoma: left-sided resection is preferred when possible

PB Olthof, JI Erdmann, R Alikhanov, R Charco… - Annals of Surgical …, 2024 - Springer
Background A right-or left-sided liver resection can be considered in about half of patients
with perihilar cholangiocarcinoma (pCCA), depending on tumor location and vascular …

[HTML][HTML] Short-and long-term outcomes after hemihepatectomy for perihilar cholangiocarcinoma: does left or right side matter?

LC Franken, PB Olthof, JI Erdmann… - … Surgery and Nutrition, 2021 - ncbi.nlm.nih.gov
Background The only potentially curative option for patients with perihilar
cholangiocarcinoma (PHC) is resection, typically an extrahepatic bile duct resection in …