The p38 MAPK pathway is well known for its role in transducing stress signals from the
environment. Many key players and regulatory mechanisms of this signaling cascade have …

The mitogen-activated protein kinase (MAPK) signaling pathway is the primary regulatory
module of various cellular processes such as cell proliferation, differentiation, and stress …

Cancer is currently the second leading cause of death globally and is expected to be
responsible for approximately 9.6 million deaths in 2018. With an unprecedented …

FMS-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that is expressed almost
exclusively in the hematopoietic compartment. Its ligand, FLT3 ligand (FL), induces …

Contrast-induced nephropathy (CIN) or contrast-induced acute kidney injury (CI-AKI) is an
iatrogenic acute kidney injury observed after intravascular administration of contrast media …

Introduction Approximately 2% of lung adenocarcinomas have BRAF (v-Raf murine sarcoma
viral oncogene homolog B) mutations, including V600E and other types. Vemurafenib …

A major challenge in cancer treatment is predicting the clinical response to anti-cancer
drugs on a personalized basis. The success of such a task largely depends on the ability to …

Small nucleolar RNAs (snoRNAs) are conserved noncoding RNAs best studied as
ribonucleoprotein (RNP) guides in RNA modification,. To explore their role in cancer, we …

Non-small cell lung cancer (NSCLC) is a prominent subtype of lung carcinoma that accounts
for the majority of cancer-related deaths globally, and it is responsible for about 80% to 85 …

Resistance is a significant limitation to the effectiveness of cancer therapies. The PI3K/Akt
and MAP kinase pathways play important roles in a variety of normal cellular processes and …