Curcumin and gastric cancer: A review on mechanisms of action

T Hassanalilou, S Ghavamzadeh, L Khalili - Journal of Gastrointestinal …, 2019 - Springer
Abstract Background and Aim Gastric cancer, as the fourth cause of death in women and
third in men with malignant tumors, is now threatening people's lives worldwide. Natural anti …

Caspases in Alzheimer's disease: mechanism of activation, role, and potential treatment

P Wójcik, MK Jastrzębski, A Zięba, D Matosiuk… - Molecular …, 2024 - Springer
With the aging of the population, treatment of conditions emerging in old age, such as
neurodegenerative disorders, has become a major medical challenge. Of these, Alzheimer's …

Curcumin induces apoptosis in SGC-7901 gastric adenocarcinoma cells via regulation of mitochondrial signaling pathways

X Xue, JL Yu, DQ Sun, F Kong, X Qu… - Asian Pacific Journal …, 2014 - koreascience.kr
Curcumin, a polyphenol compound derived from the rhizome of the plant Curcuma longa L.
has been verified as an anticancer compound against several types of cancer. However …

Solid lipid nanoparticles enhanced the neuroprotective role of curcumin against epilepsy through activation of Bcl-2 family and P38 MAPK pathways

R Huang, Y Zhu, L Lin, S Song, L Cheng… - ACS Chemical …, 2020 - ACS Publications
Oxidative stress of neurons caused by a series of complex neuropathological processes will
induce certain neurodegenerative disorders including epilepsy. Curcumin (Cur) is an …

[HTML][HTML] Amyloid β induces early changes in the ribosomal machinery, cytoskeletal organization and oxidative phosphorylation in retinal photoreceptor cells

L Deng, K Pushpitha, C Joseph, V Gupta… - Frontiers in Molecular …, 2019 - frontiersin.org
Amyloid β (Aβ) accumulation and its aggregation is characteristic molecular feature of the
development of Alzheimer's disease (AD). More recently, Aβ has been suggested to be …

Supramolecular organizing centers at the interface of inflammation and neurodegeneration

P Sušjan-Leite, TŽ Ramuta, E Boršić, S Orehek… - Frontiers in …, 2022 - frontiersin.org
The pathogenesis of neurodegenerative diseases involves the accumulation of misfolded
protein aggregates. These deposits are both directly toxic to neurons, invoking loss of cell …

Contribution of Apaf-1 to the pathogenesis of cancer and neurodegenerative diseases

R Shakeri, A Kheirollahi, J Davoodi - Biochimie, 2021 - Elsevier
Deregulation of apoptosis is associated with various pathologies, such as
neurodegenerative disorders at one end of the spectrum and cancer at the other end …

Propolis cinnamic acid derivatives induce apoptosis through both extrinsic and intrinsic apoptosis signaling pathways and modulate of miRNA expression

M Kumazaki, H Shinohara, K Taniguchi, N Yamada… - Phytomedicine, 2014 - Elsevier
Propolis cinnamic acid derivatives have a number of biological activities including anti-
oxidant and anti-cancer ones. In this study, we aimed to elucidate the mechanism of the anti …

An expeditious and facile method of amyloid beta (1–42) purification

MA Haque, IS Park - Plos one, 2024 - journals.plos.org
For the study of amyloid beta (Aβ) associated toxicity which is supposed to be the main
pathological agent in Alzheimer's disease (AD), it is important to secure Aβ peptide with …

[HTML][HTML] GRPa-PRS: A risk stratification method to identify genetically-regulated pathways in polygenic diseases

X Li, BS Fernandes, A Liu, J Chen, X Chen, Z Zhao… - medRxiv, 2023 - ncbi.nlm.nih.gov
Background: Polygenic risk scores (PRS) are tools used to evaluate an individual's
susceptibility to polygenic diseases based on their genetic profile. A considerable proportion …