Artificial intelligence-enabled quantitative phase imaging methods for life sciences

J Park, B Bai, DH Ryu, T Liu, C Lee, Y Luo, MJ Lee… - Nature …, 2023 - nature.com
Quantitative phase imaging, integrated with artificial intelligence, allows for the rapid and
label-free investigation of the physiology and pathology of biological systems. This review …

Quantitative phase imaging: recent advances and expanding potential in biomedicine

TL Nguyen, S Pradeep, RL Judson-Torres, J Reed… - ACS …, 2022 - ACS Publications
Quantitative phase imaging (QPI) is a label-free, wide-field microscopy approach with
significant opportunities for biomedical applications. QPI uses the natural phase shift of light …

Single-shot isotropic differential interference contrast microscopy

X Wang, H Wang, J Wang, X Liu, H Hao, YS Tan… - Nature …, 2023 - nature.com
Differential interference contrast (DIC) microscopy allows high-contrast, low-phototoxicity,
and label-free imaging of transparent biological objects, and has been applied in the field of …

Transport of intensity diffraction tomography with non-interferometric synthetic aperture for three-dimensional label-free microscopy

J Li, N Zhou, J Sun, S Zhou, Z Bai, L Lu… - Light: Science & …, 2022 - nature.com
We present a new label-free three-dimensional (3D) microscopy technique, termed transport
of intensity diffraction tomography with non-interferometric synthetic aperture (TIDT-NSA) …

Quantitative phase imaging based on holography: trends and new perspectives

Z Huang, L Cao - Light: Science & Applications, 2024 - nature.com
Abstract In 1948, Dennis Gabor proposed the concept of holography, providing a pioneering
solution to a quantitative description of the optical wavefront. After 75 years of development …

Single-shot quantitative phase gradient microscopy using a system of multifunctional metasurfaces

H Kwon, E Arbabi, SM Kamali, MS Faraji-Dana… - Nature …, 2020 - nature.com
Quantitative phase imaging (QPI) of transparent samples plays an essential role in multiple
biomedical applications, and miniaturizing these systems will enable their adoption into …

Quantitative phase imaging in biomedicine

YK Park, C Depeursinge, G Popescu - Nature photonics, 2018 - nature.com
Quantitative phase imaging (QPI) has emerged as a valuable method for investigating cells
and tissues. QPI operates on unlabelled specimens and, as such, is complementary to …

All‐optical phase recovery: diffractive computing for quantitative phase imaging

D Mengu, A Ozcan - Advanced Optical Materials, 2022 - Wiley Online Library
Quantitative phase imaging (QPI) is a label‐free computational imaging technique that
provides optical path length information of specimens. In modern implementations, the …

Phase imaging with computational specificity (PICS) for measuring dry mass changes in sub-cellular compartments

ME Kandel, YR He, YJ Lee, THY Chen… - Nature …, 2020 - nature.com
Due to its specificity, fluorescence microscopy has become a quintessential imaging tool in
cell biology. However, photobleaching, phototoxicity, and related artifacts continue to limit …

High-resolution 3D refractive index microscopy of multiple-scattering samples from intensity images

S Chowdhury, M Chen, R Eckert, D Ren, F Wu… - Optica, 2019 - opg.optica.org
Optical diffraction tomography (ODT) reconstructs a sample's volumetric refractive index (RI)
to create high-contrast, quantitative 3D visualizations of biological samples. However …