Obesity is a risk factor for developing type 2 diabetes and cardiovascular disease and has
quickly become a worldwide pandemic with few tangible and safe treatment options …

Our understanding of the functions of ceramide signaling has advanced tremendously over
the past decade. In this review, we focus on the roles and regulation of neutral …

La céramide, un nouveau second messager et lipide bioactif, est principalement formée lors
de l'hydrolyse de la sphingomyéline par des sphingomyélinases. Au moins deux …

Objective—Atherosclerosis is a chronic inflammatory response of the arterial wall to injury.
High-mobility group box 1 (HMGB1) is a DNA-binding protein, which on release from cells …

The levels of L-arginine, a cationic, semi-essential amino acid, are often controlled within a
cell at the level of local availability through biosynthesis. The importance of this temporal …

The only known function of NAD (P) H oxidases is to produce reactive oxygen species
(ROS). Skeletal muscles express three isoforms of NAD (P) H oxidases (Nox1, Nox2, and …

UVA radiation is a major environmental stress on skin, causing acute and chronic
photodamage. These responses are mediated by reactive oxygen species (ROS), although …

Tumor microenvironment is fundamental for cancer progression and chemoresistance.
Among stromal cells tumor-associated macrophages (TAMs) represent the largest …

Sphingolipids are a class of bioactive lipids, which are key modulators of an increasing
number of physiologic and pathophysiologic processes that include cell cycle, apoptosis …

Objective—Tumor necrosis factor α (TNF-α), a key proinflammatory cytokine acting on the
endothelium, activates endothelial nitric oxide synthase (eNOS). We have examined the …