The dimerization of RAF kinases represents a key event in their activation cycle and in
RAS/ERK pathway activation. Genetic, biochemical and structural approaches provided key …

Simple Summary Cell biologists trust in standard media for analyzing cellular functions and
for the specification of target-oriented drug efficacies in cell culture settings. Here, we …

Resistance to pharmacological treatments is a major public health challenge. Here, we
introduce Resistor—a structure-and sequence-based algorithm that prospectively predicts …

Nirmatrelvir was the first protease inhibitor (PI) specifically developed against the SARS-
CoV-2 main protease (3CL pro/M pro) and licensed for clinical use. As SARS-CoV-2 …

Protein kinases take the center stage in numerous signaling pathways by phosphorylating
compartmentalized protein substrates for controlling cell proliferation, cell cycle and …

Numerous kinases act as central nodes of cellular signaling networks. As such, many of
these enzymes function as molecular switches for coordinating spatiotemporal signal …

The selective targeting of mutated kinases in cancer therapies has the potential to improve
therapeutic success and thereby the survival of patients. In the case of melanoma, the …

Mutations at different stages of the mitogen-activated protein kinase (MAPK) signaling
pathway lead to aberrant activation of the involved protein kinase entities. These oncogenic …

Protein kinases act as central molecular switches in the control of cellular functions.
Alterations in the regulation and function of protein kinases may provoke diseases including …

Resistance to pharmacological treatments, such as to antibiotics or cancer therapeutics,
ablates the efficacy of drugs and is a major public health challenge [,]. Accurate, prospective …