Vascular endothelial cells form the inner layer of blood vessels where they have a key role
in the development and maintenance of the functional circulatory system and provide …

Permanent fibrosis and chronic deterioration of heart function in patients after myocardial
infarction present a major health-care burden worldwide. In contrast to the restricted …

The formation of new blood vessels after myocardial infarction (MI) is essential for the
survival of existing and regenerated cardiac tissue. However, the extent of endogenous …

Despite decades of research, regeneration of the infarcted human heart remains an unmet
ambition. A significant obstacle facing experimental regenerative therapies is the hostile …

To maintain homeostasis in the heart, endothelial cells and cardiomyocytes engage in
dynamic cross-talk through paracrine signals that regulate both cardiac development and …

Transcription factors (TFs) play a crucial role in regulating the dynamic and precise patterns
of gene expression required for the initial specification of endothelial cells (ECs), and during …

Most cell fate trajectories during development follow a diverging, tree-like branching pattern,
but the opposite can occur when distinct progenitors contribute to the same cell type. During …

Rationale: The molecular mechanisms underlying the formation of coronary arteries during
development and during cardiac neovascularization after injury are poorly understood …

Brain natriuretic peptide (BNP) treatment increases heart function and decreases heart
dilation after myocardial infarction (MI). Here, we investigated whether part of the …

Background Proper function of endothelial cells is critical for vascular integrity and
organismal survival. Studies over the past 2 decades have identified 2 members of the KLF …