Advances in non-dopaminergic treatments for Parkinson's disease

S Stayte, B Vissel - Frontiers in neuroscience, 2014 - frontiersin.org
Since the 1960's treatments for Parkinson's disease (PD) have traditionally been directed to
restore or replace dopamine, with L-Dopa being the gold standard. However, chronic L …

Pathophysiological mechanisms of antipsychotic-induced parkinsonism

EE Vaiman, NA Shnayder, AK Khasanova, AI Strelnik… - Biomedicines, 2022 - mdpi.com
Among neurological adverse reactions in patients with schizophrenia treated with
antipsychotics (APs), drug-induced parkinsonism (DIP) is the most common motility disorder …

Nose-to-brain delivery of chrysin transfersomal and composite vesicles in doxorubicin-induced cognitive impairment in rats: Insights on formulation, oxidative stress …

SS Ibrahim, OGA Elseoud, MH Mohamedy, MM Amer… - …, 2021 - Elsevier
Many cancer survivors suffer from chemotherapy-induced cognitive impairment known as
'Chemobrain'. Doxorubicin-topoisomerase II inhibitor-is widely used in breast cancer …

Chemical characterization of the polyphenolic rich fraction of Thunbergia erecta and its therapeutic potential against doxorubicin and cyclophosphamide-induced …

MIG El-Din, MY George, FS Youssef - Journal of ethnopharmacology, 2023 - Elsevier
Abstract Ethnopharmacological relevance Thunbergia erecta (Benth.) was traditionally used
as anxiolytic, sedative and antidepressant. Aim of the study The study aimed to characterize …

Subcutaneous rotenone rat model of Parkinson's disease: Dose exploration study

ZN Zhang, JS Zhang, J Xiang, ZH Yu, W Zhang, M Cai… - Brain research, 2017 - Elsevier
Subcutaneous administration of rotenone has recently attracted attention because of its
convenience, simplicity and efficacy in replicating features of Parkinson's disease (PD) in …

Protective effect of Curcumin, the active principle of turmeric (Curcuma longa) in haloperidol-induced orofacial dyskinesia and associated behavioural, biochemical …

M Bishnoi, K Chopra, SK Kulkarni - Pharmacology Biochemistry and …, 2008 - Elsevier
Tardive dyskinesia (TD) is a motor disorder of the orofacial region resulting from chronic
neuroleptic treatment. A high incidence and irreversibility of this hyperkinetic disorder has …

Neuroprotective effects of indole-3-carbinol on the rotenone rat model of Parkinson's disease: Impact of the SIRT1-AMPK signaling pathway

KA Mohamad, RN El-Naga, SA Wahdan - Toxicology and Applied …, 2022 - Elsevier
Parkinson's disease (PD) is the second most common progressive neurodegenerative
disorder. Although mounting studies have been conducted, no effective therapy is available …

Tetramethylpyrazine ameliorates rotenone-induced Parkinson's disease in rats: involvement of its anti-inflammatory and anti-apoptotic actions

HE Michel, MG Tadros, A Esmat, AE Khalifa… - Molecular …, 2017 - Springer
Parkinson's disease (PD) is a slowly progressive neurodegenerative movement disorder.
Apoptosis, neuroinflammation, and oxidative stress are the current hypothesized …

Potential therapeutic antipsychotic effects of Naringin against ketamine-induced deficits in rats: involvement of Akt/GSK-3β and Wnt/β-catenin signaling pathways

MY George, ET Menze, A Esmat, MG Tadros… - Life sciences, 2020 - Elsevier
Aim Schizophrenia is a chronic, disabling and one of the major neurological illnesses
affecting nearly 1% of the global population. Currently available antipsychotic medications …

[PDF][PDF] Beneficial effect of vitamin E in rotenone induced model of PD: behavioural, neurochemical and biochemical study

N Sharma, B Nehru - Experimental neurobiology, 2013 - synapse.koreamed.org
Parkinson's disease (PD) a neurodegenerative disorder for which no preventive or long-term
effective treatment strategies are available. Epidemiologic studies have failed to identify …