Innovations in biomaterials and stem cell technology have allowed for the emergence of
novel three-dimensional (3D) tissue-like structures known as organoids and spheroids. As a …

Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …

To establish and maintain organ structure and function, tissues need to balance stem cell
proliferation and differentiation rates and coordinate cell fate with position. By quantifying …

The organization of cells into epithelium depends on cell interaction with both the
extracellular matrix (ECM) and adjacent cells. The role of cell–cell adhesion in the regulation …

Centrosome amplification has long been recognized as a feature of human tumours;
however, its role in tumorigenesis remains unclear. Centrosome amplification is poorly …

In situ, cells are highly sensitive to geometrical and mechanical constraints from their
microenvironment. These parameters are, however, uncontrolled under classic culture …

The response of cells to forces is essential for tissue morphogenesis and homeostasis. This
response has been extensively investigated in interphase cells, but it remains unclear how …

How different integrins that bind to the same type of extracellular matrix protein mediate
specific functions is unclear. We report the functional analysis of β1-and αv-class integrins …

Contractile actomyosin networks are responsible for the production of intracellular forces.
There is increasing evidence that bundles of actin filaments form interconnected and …

Amyloid β (Aβ) peptides, the primary constituents of senile plaques and a hallmark in
Alzheimer's disease pathology, are generated through the sequential cleavage of amyloid …