Highlights•Microbe-derived molecules influence disease outcomes through diverse
mechanisms.•Short-chain fatty acid (SCFA) production in the gut can alter microglial …

The gut microbiota came into focus within the last years regarding being associated with or
even underlying neuropsychiatric diseases. The existence of the gut-brain-axis makes it …

Objective This study is to investigate the role of gut dysbiosis in triggering inflammation in
the brain and its contribution to Alzheimer's disease (AD) pathogenesis. Design We …

Peripheral β-amyloid (Aβ), including those contained in the gut, may contribute to the
formation of Aβ plaques in the brain, and gut microbiota appears to exert an impact on …

Simple Summary Lipopolysaccharide (LPS) derived from intestinal bacteria is linked to long-
lasting inflammation that contributes to the development of intestinal cancer. While much …

The cysteine protease legumain (also known as asparaginyl endopeptidase or δ-secretase)
is the only known mammalian asparaginyl endopeptidase and is primarily localized to the …

Being isolated from the peripheral system by the blood–brain barrier, the brain has long
been considered a completely impervious tissue. However, recent findings show that the gut …

Survival requires the integration of external information and interoceptive cues to effectively
guide advantageous behaviors, particularly foraging and other behaviors that promote …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the
accumulation of amyloid-β (Aβ) in the brain. The gut/brain axis may serve a role in AD …

Alzheimer's disease (AD) is a central nervous system disease characterised by
degenerative cognitive dysfunction and memory loss. In a society where the global …