Disturbance in the folding capacity of the endoplasmic reticulum (ER), caused by a variety of
endogenous and exogenous insults, prompts a cellular stress condition known as ER stress …

Introduction: Human cancers are genetically and epigenetically heterogeneous and have
the capacity to commandeer a variety of cellular processes to aid in their survival, growth …

The continuous rise in skin cancer incidence highlights an imperative for improved skin
cancer prevention. Topical calcipotriol-plus–5-fluorouracil (calcipotriol-plus–5-FU) …

Cancer cells are exposed to various intrinsic and extrinsic factors that disrupt protein
homeostasis, producing endoplasmic reticulum (ER) stress. To cope with these situations …

Endoplasmic reticulum (ER) stress disrupts among others protein homeostasis in cells
leading to the activation of the unfolded protein response (UPR) that is crucial for restoring …

Glucose regulated protein 78 (GRP78) has long been recognized as a molecular chaperone
in the endoplasmic reticulum (ER) and can be induced by the ER stress response. Besides …

First identified almost two decades ago as a novel gene differentially expressed in human
melanoma cells induced to terminally differentiate, MDA-7/IL-24 has since shown great …

Treatment of several types of cancer such as lung, breast, prostate, and pancreas has
shown notable progresses in the past decades. However, after an initial response, tumors …

Limited options are available for treating patients with advanced prostate cancer (PC).
Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24), an IL-10 family …

Interleukin 24 (IL-24) is an important pleiotropic immunoregulatory cytokine, whose gene is
located in human chromosome 1q32-33. IL-24's signaling pathways have diverse biological …