The principal targets for anti-chemokine therapy in inflammatory bowel disease (IBD) have
been the receptors CCR9 and CXCR3 and their respective ligands CCL25 and CXCL10 …

MicroRNAs (miRNAs) are small noncoding conserved RNAs containing 19 to 24 nucleotides
that are regulators of post-translational modifications and are involved in the majority of …

Crohn's disease (CD) and ulcerative colitis (UC), two forms of inflammatory bowel disease
(IBD), are chronic, relapsing, and tissue destructive lesions that are accompanied by the …

Background Aryl hydrocarbon receptor (AhR), a transcription factor of the bHLH/PAS family,
is well characterized to regulate the biochemical and toxic effects of environmental …

Resveratrol is a naturally occurring polyphenol that exhibits pleiotropic health beneficial
effects, including anti-inflammatory, cardio-protective, and cancer-protective activities. It is …

Chronic infection with hepatitis C virus (HCV) is a major public health problem, with nearly
170 million infected individuals worldwide. Current treatment for chronic infection is a …

Inflammatory bowel disease is a chronic, relapsing, and tissue-destructive disease.
Resveratrol (3, 4, 5-trihydroxy-trans-stilbene), a naturally occurring polyphenol that exhibits …

Objective Interferon-γ-inducible protein-10 (IP-10 or CXCL10) plays a role in inflammatory
cell migration and epithelial cell survival and migration. It is expressed in higher levels in the …

Background CD8+ T cell trafficking to the tumor site is essential for effective colorectal
cancer (CRC) immunotherapy. However, the mechanism underlying CD8+ T cell infiltration …

Colitis-associated colorectal cancer (CAC) develops from chronic intestinal inflammation.
Dihydroartemisinin (DHA) is an antimalarial drug exhibiting anti-inflammatory and anti-tumor …