Neural circuits are assembled with remarkable precision during embryonic development,
and the selectivity inherent in their formation helps to define the behavioural repertoire of the …

Cortical interneurons are a diverse group of neurons that project locally and are crucial for
regulating information processing and flow throughout the cortex. Recent studies in mice …

Bromodomain inhibition comprises a promising therapeutic strategy in cancer, particularly
for hematologic malignancies. To date, however, genomic biomarkers to direct clinical …

Transcription factors regulate the molecular, morphological, and physiological
characteristics of neurons and generate their impressive cell-type diversity. To gain insight …

The Drosophila ventral nerve cord (VNC) receives and processes descending signals from
the brain to produce a variety of coordinated locomotor outputs. It also integrates sensory …

The LIM domain is a zinc finger structure that is present in several types of proteins,
including homeodomain transcription factors, kinases and proteins that consist of several …

In mammals, innate reproductive and defensive behaviors are mediated by anatomically
segregated connections between the amygdala and hypothalamus. This anatomic …

Homeobox genes play fundamental roles in development. They can be subdivided into
several subfamilies, one of which is the LIM-homeobox subfamily. The primary structure of …

The generation of distinct classes of neurons at defined positions is a fundamental step in
the development of the vertebrate central nervous system. Recent work has begun to reveal …

The connections formed between sensory and motor neurons (MNs) play a critical role in the
control of motor behavior. During development, the axons of proprioceptive sensory neurons …