A key barrier to the development of gene therapy remains the lack of safe, efficient and
easily controllable vehicles for gene delivery. The fundamental problems associated with the …

Advances in the field of nanomedicine have led to the development of various gene carriers
with desirable cellular responses. However, unfavorable stability and physicochemical …

We have developed a novel nanoparticle delivery system fabricated from polyethylenimine
(PEI) and poly (d, l-lactide-co-glycolide)(PLGA), which were able to deliver the …

Docetaxel (DTX) is commonly used for breast cancer treatment. Tween 80 used for DTX
dissolution in its clinical formulation causes severe hypersensitivity and other adverse …

The physiological condition of the human body is a composite of different environments,
each with its own parameters that may differ under normal, as well as diseased conditions …

Vascular networks are the first sites exposed to cationic polymer nanoparticles (NPs)
administered intravenously, and thus function as a barrier for NPs reaching the target organ …

Background Co-delivery of anticancer drugs and gene is promising to generate synergistic
anticancer effects. Surface modification of nanocarriers with specific ligands could further …

RNA interference technology has been widely applied in biomedical therapy in recent years.
A type of small RNA molecule–siRNA could regulate the expression of disease related …

Malignant melanoma is a highly aggressive type of cancer that requires radical treatment
strategies to inhibit the cancer cell progression and metastasis. In recent years, preclinical …

Gene therapy holds a great promise and has been extensively investigated to improve bone
formation and regeneration therapies in bone tissue engineering. A variety of osteogenic …