Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases

G Lou, Z Chen, M Zheng, Y Liu - Experimental & molecular medicine, 2017 - nature.com
The administration of mesenchymal stem cells (MSCs) as a therapy for liver disease holds
great promise. MSCs can differentiate into hepatocytes, reduce liver inflammation, promote …

Mesenchymal stem cells: key players in cancer progression

SM Ridge, FJ Sullivan, SA Glynn - Molecular cancer, 2017 - Springer
Tumour progression is dependent on the interaction between tumour cells and cells of the
surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell …

Next-generation stem cells—ushering in a new era of cell-based therapies

EA Kimbrel, R Lanza - Nature Reviews Drug Discovery, 2020 - nature.com
Naturally occurring stem cells isolated from humans have been used therapeutically for
decades. This has primarily involved the transplantation of primary cells such as …

Senescence in human mesenchymal stem cells: functional changes and implications in stem cell-based therapy

V Turinetto, E Vitale, C Giachino - International journal of molecular …, 2016 - mdpi.com
Regenerative medicine is extensively interested in developing cell therapies using
mesenchymal stem cells (MSCs), with applications to several aging-associated diseases …

[HTML][HTML] Effect of stromal cells in tumor microenvironment on metastasis initiation

S Guo, CX Deng - International journal of biological sciences, 2018 - ncbi.nlm.nih.gov
The cellular environment where tumor cells reside is called the tumor microenvironment
(TME), which consists of borders, blood vessels, lymph vessels, extracellular matrix (ECM) …

Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: a new approach for drug delivery

L Pascucci, V Coccè, A Bonomi, D Ami… - Journal of controlled …, 2014 - Elsevier
Mesenchymal stromal cells (MSCs) have been proposed for delivering anticancer agents
because of their ability to home in on tumor microenvironment. We found that MSCs can …

MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR/HIF-1α/VEGF signaling axis in …

K Pakravan, S Babashah, M Sadeghizadeh, SJ Mowla… - Cellular oncology, 2017 - Springer
Background Human mesenchymal stem cells (MSCs) have been shown to be involved in
the formation and modulation of tumor stroma and in interacting with tumor cells, partly …

Concise review: mesenchymal stem cell-based drug delivery: the good, the bad, the ugly, and the promise

TEG Krueger, DLJ Thorek… - Stem cells …, 2018 - academic.oup.com
The development of mesenchymal stem cells (MSCs) as cell-based drug delivery vectors for
numerous clinical indications, including cancer, has significant promise. However, a …

Mesenchymal stem/stromal cell-derived exosomes in regenerative medicine and cancer; overview of development, challenges, and opportunities

A Hassanzadeh, HS Rahman, A Markov… - Stem cell research & …, 2021 - Springer
Recently, mesenchymal stem/stromal cells (MSCs) and their widespread biomedical
applications have attracted great consideration from the scientific community around the …

Exosomes derived from mesenchymal stem cells suppress angiogenesis by down-regulating VEGF expression in breast cancer cells

JK Lee, SR Park, BK Jung, YK Jeon, YS Lee, MK Kim… - PloS one, 2013 - journals.plos.org
Exosomes are small membrane vesicles released by a variety of cell types. Exosomes
contain genetic materials, such as mRNAs and microRNAs (miRNAs), implying that they …