Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases
The administration of mesenchymal stem cells (MSCs) as a therapy for liver disease holds
great promise. MSCs can differentiate into hepatocytes, reduce liver inflammation, promote …
great promise. MSCs can differentiate into hepatocytes, reduce liver inflammation, promote …
Mesenchymal stem cells: key players in cancer progression
SM Ridge, FJ Sullivan, SA Glynn - Molecular cancer, 2017 - Springer
Tumour progression is dependent on the interaction between tumour cells and cells of the
surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell …
surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell …
Next-generation stem cells—ushering in a new era of cell-based therapies
EA Kimbrel, R Lanza - Nature Reviews Drug Discovery, 2020 - nature.com
Naturally occurring stem cells isolated from humans have been used therapeutically for
decades. This has primarily involved the transplantation of primary cells such as …
decades. This has primarily involved the transplantation of primary cells such as …
Senescence in human mesenchymal stem cells: functional changes and implications in stem cell-based therapy
V Turinetto, E Vitale, C Giachino - International journal of molecular …, 2016 - mdpi.com
Regenerative medicine is extensively interested in developing cell therapies using
mesenchymal stem cells (MSCs), with applications to several aging-associated diseases …
mesenchymal stem cells (MSCs), with applications to several aging-associated diseases …
[HTML][HTML] Effect of stromal cells in tumor microenvironment on metastasis initiation
The cellular environment where tumor cells reside is called the tumor microenvironment
(TME), which consists of borders, blood vessels, lymph vessels, extracellular matrix (ECM) …
(TME), which consists of borders, blood vessels, lymph vessels, extracellular matrix (ECM) …
Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: a new approach for drug delivery
L Pascucci, V Coccè, A Bonomi, D Ami… - Journal of controlled …, 2014 - Elsevier
Mesenchymal stromal cells (MSCs) have been proposed for delivering anticancer agents
because of their ability to home in on tumor microenvironment. We found that MSCs can …
because of their ability to home in on tumor microenvironment. We found that MSCs can …
MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR/HIF-1α/VEGF signaling axis in …
Background Human mesenchymal stem cells (MSCs) have been shown to be involved in
the formation and modulation of tumor stroma and in interacting with tumor cells, partly …
the formation and modulation of tumor stroma and in interacting with tumor cells, partly …
Concise review: mesenchymal stem cell-based drug delivery: the good, the bad, the ugly, and the promise
TEG Krueger, DLJ Thorek… - Stem cells …, 2018 - academic.oup.com
The development of mesenchymal stem cells (MSCs) as cell-based drug delivery vectors for
numerous clinical indications, including cancer, has significant promise. However, a …
numerous clinical indications, including cancer, has significant promise. However, a …
Mesenchymal stem/stromal cell-derived exosomes in regenerative medicine and cancer; overview of development, challenges, and opportunities
A Hassanzadeh, HS Rahman, A Markov… - Stem cell research & …, 2021 - Springer
Recently, mesenchymal stem/stromal cells (MSCs) and their widespread biomedical
applications have attracted great consideration from the scientific community around the …
applications have attracted great consideration from the scientific community around the …
Exosomes derived from mesenchymal stem cells suppress angiogenesis by down-regulating VEGF expression in breast cancer cells
JK Lee, SR Park, BK Jung, YK Jeon, YS Lee, MK Kim… - PloS one, 2013 - journals.plos.org
Exosomes are small membrane vesicles released by a variety of cell types. Exosomes
contain genetic materials, such as mRNAs and microRNAs (miRNAs), implying that they …
contain genetic materials, such as mRNAs and microRNAs (miRNAs), implying that they …