It is increasingly accepted that early cognitive impairment in Alzheimer's disease results in
considerable part from synaptic dysfunction caused by the accumulation of a range of …

Alzheimer's disease (AD) is the most common form of dementia in the elderly, and affects
millions of people worldwide. As the number of AD cases continues to increase in both …

Microglia-mediated synaptic loss contributes to the development of cognitive impairments in
Alzheimer's disease (AD). However, the basis for this immune-mediated attack on synapses …

The misfolding of the cellular prion protein (PrP C) causes fatal neurodegenerative
diseases. Yet PrP C is highly conserved in mammals, suggesting that it exerts beneficial …

Neurodegenerative diseases are an enormous public health problem, affecting tens of
millions of people worldwide. Nearly all of these diseases are characterized by …

Alzheimer's disease (AD) is the most common form of dementia, with over 37 million
sufferers worldwide and a global cost of over $600 billion. There is currently no cure for AD …

Many protein folding diseases are intimately associated with accumulation of amyloid
aggregates. The amyloid materials formed by different proteins/peptides share many …

Alzheimer's disease is a common neurodegenerative, progressive, and fatal disorder.
Generation and deposition of amyloid beta (Aβ) peptides associate with its pathogenesis …

Amyloid-β oligomers (AβOs) are the most important toxic species in the brain of Alzheimer's
disease (AD) patient. AβOs, therefore, are considered reliable molecular biomarkers for the …

The precise molecular mechanism of how misfolded α-synuclein (α-Syn) accumulates and
spreads in synucleinopathies is still unknown. Here, we show the role of the cellular prion …