Concepts and core principles of fragment-based drug design
P Kirsch, AM Hartman, AKH Hirsch, M Empting - Molecules, 2019 - mdpi.com
In this review, a general introduction to fragment-based drug design and the underlying
concepts is given. General considerations and methodologies ranging from library …
concepts is given. General considerations and methodologies ranging from library …
[HTML][HTML] Affinity measurement of strong ligands with NMR spectroscopy: Limitations and ways to overcome them
C Dalvit, I Gmür, P Rößler, AD Gossert - Progress in Nuclear Magnetic …, 2023 - Elsevier
NMR spectroscopy is currently extensively used in binding assays for hit identification, but its
use in dissociation constant determination is more limited when compared to other …
use in dissociation constant determination is more limited when compared to other …
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB
R Moliner, M Girych, CA Brunello, V Kovaleva… - Nature …, 2023 - nature.com
Psychedelics produce fast and persistent antidepressant effects and induce neuroplasticity
resembling the effects of clinically approved antidepressants. We recently reported that …
resembling the effects of clinically approved antidepressants. We recently reported that …
[HTML][HTML] Antidepressant drugs act by directly binding to TRKB neurotrophin receptors
It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical
antidepressant effect. We discovered that the transmembrane domain of tyrosine kinase …
antidepressant effect. We discovered that the transmembrane domain of tyrosine kinase …
Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins
Single-molecule Förster-resonance energy transfer (smFRET) experiments allow the study
of biomolecular structure and dynamics in vitro and in vivo. We performed an international …
of biomolecular structure and dynamics in vitro and in vivo. We performed an international …
Drugging an undruggable pocket on KRAS
D Kessler, M Gmachl, A Mantoulidis… - Proceedings of the …, 2019 - National Acad Sciences
The 3 human RAS genes, KRAS, NRAS, and HRAS, encode 4 different RAS proteins which
belong to the protein family of small GTPases that function as binary molecular switches …
belong to the protein family of small GTPases that function as binary molecular switches …
The virus-induced cyclic dinucleotide 2′ 3′-c-di-GMP mediates STING-dependent antiviral immunity in Drosophila
H Cai, L Li, KM Slavik, J Huang, T Yin, X Ai, L Hédelin… - Immunity, 2023 - cell.com
In mammals, the enzyme cGAS senses the presence of cytosolic DNA and synthesizes the
cyclic dinucleotide (CDN) 2′ 3′-cGAMP, which triggers STING-dependent immunity. In …
cyclic dinucleotide (CDN) 2′ 3′-cGAMP, which triggers STING-dependent immunity. In …
Killing of Staphylococcus aureus persisters by a multitarget natural product chrysomycin A
J Jia, M Zheng, C Zhang, B Li, C Lu, Y Bai, Q Tong… - Science …, 2023 - science.org
Staphylococcus aureus poses a severe public health problem as one of the vital causative
agents of healthcare-and community-acquired infections. There is a globally urgent need for …
agents of healthcare-and community-acquired infections. There is a globally urgent need for …
Receptor kinase THESEUS1 is a rapid alkalinization factor 34 receptor in Arabidopsis
The growth of plants, like that of other walled organisms, depends on the ability of the cell
wall to yield without losing its integrity. In this context, plant cells can sense the perturbation …
wall to yield without losing its integrity. In this context, plant cells can sense the perturbation …
[HTML][HTML] Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α
Exercise benefits the human body in many ways. Irisin is secreted by muscle, increased with
exercise, and conveys physiological benefits, including improved cognition and resistance …
exercise, and conveys physiological benefits, including improved cognition and resistance …