In this review, a general introduction to fragment-based drug design and the underlying
concepts is given. General considerations and methodologies ranging from library …

NMR spectroscopy is currently extensively used in binding assays for hit identification, but its
use in dissociation constant determination is more limited when compared to other …

Psychedelics produce fast and persistent antidepressant effects and induce neuroplasticity
resembling the effects of clinically approved antidepressants. We recently reported that …

It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical
antidepressant effect. We discovered that the transmembrane domain of tyrosine kinase …

Single-molecule Förster-resonance energy transfer (smFRET) experiments allow the study
of biomolecular structure and dynamics in vitro and in vivo. We performed an international …

The 3 human RAS genes, KRAS, NRAS, and HRAS, encode 4 different RAS proteins which
belong to the protein family of small GTPases that function as binary molecular switches …

In mammals, the enzyme cGAS senses the presence of cytosolic DNA and synthesizes the
cyclic dinucleotide (CDN) 2′ 3′-cGAMP, which triggers STING-dependent immunity. In …

Staphylococcus aureus poses a severe public health problem as one of the vital causative
agents of healthcare-and community-acquired infections. There is a globally urgent need for …

The growth of plants, like that of other walled organisms, depends on the ability of the cell
wall to yield without losing its integrity. In this context, plant cells can sense the perturbation …

Exercise benefits the human body in many ways. Irisin is secreted by muscle, increased with
exercise, and conveys physiological benefits, including improved cognition and resistance …