FTO in cancer: functions, molecular mechanisms, and therapeutic implications

Y Li, R Su, X Deng, Y Chen, J Chen - Trends in cancer, 2022 - cell.com
N 6-methyladenosine (m 6 A) is the most abundant internal modification in mRNA that
affects RNA processing, stability, and translation. Discovered as the first RNA m 6 A …

Methylation across the central dogma in health and diseases: new therapeutic strategies

R Liu, E Zhao, H Yu, C Yuan, MN Abbas… - Signal Transduction and …, 2023 - nature.com
The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

Melatonin: regulation of biomolecular condensates in neurodegenerative disorders

D Loh, RJ Reiter - Antioxidants, 2021 - mdpi.com
Biomolecular condensates are membraneless organelles (MLOs) that form dynamic,
chemically distinct subcellular compartments organizing macromolecules such as proteins …

Oncogenic and tumor-suppressive functions of the RNA demethylase FTO

HR Zuidhof, CF Calkhoven - Cancer Research, 2022 - AACR
The epitranscriptome represents the more than 140 types of chemically varying and
reversable RNA modifications affecting RNA fate. Among these, the most relevant for this …

m6A‐Dependent Modulation via IGF2BP3/MCM5/Notch Axis Promotes Partial EMT and LUAD Metastasis

X Yang, Q Bai, W Chen, J Liang, F Wang… - Advanced …, 2023 - Wiley Online Library
The importance of mRNA N6‐methyladenosine (m6A) modification during tumor metastasis
is controversial as it plays distinct roles in different biological contexts. Moreover, how …

Regulation of m6A modification on ferroptosis and its potential significance in radiosensitization

X Chen, L Zhang, Y He, S Huang, S Chen… - Cell Death …, 2023 - nature.com
Radiotherapy is often used to treat various types of cancers, but radioresistance greatly
limits the clinical efficiency. Recent studies have shown that radiotherapy can lead to …

Epitranscriptic regulation of HRAS by N6-methyladenosine drives tumor progression

Y Pan, Y Gu, T Liu, Q Zhang, F Yang… - Proceedings of the …, 2023 - National Acad Sciences
Overexpression of Ras, in addition to the oncogenic mutations, occurs in various human
cancers. However, the mechanisms for epitranscriptic regulation of RAS in tumorigenesis …

The multifaceted functions of the Fat mass and Obesity-associated protein (FTO) in normal and cancer cells

S Relier, E Rivals, A David - RNA biology, 2022 - Taylor & Francis
The last decade has seen mRNA modification emerge as a new layer of gene expression
regulation. The Fat mass and obesity-associated protein (FTO) was the first identified eraser …

[HTML][HTML] Nanomaterial-assisted CRISPR gene-engineering–A hallmark for triple-negative breast cancer therapeutics advancement

J Farheen, NS Hosmane, R Zhao, Q Zhao, MZ Iqbal… - Materials Today Bio, 2022 - Elsevier
Triple-negative breast cancer (TNBC) is the most violent class of tumor and accounts for 20–
24% of total breast carcinoma, in which frequently rare mutation occurs in high frequency …

FTO inhibits epithelial ovarian cancer progression by destabilising SNAI1 mRNA through IGF2BP2

M Sun, X Zhang, F Bi, D Wang, X Zhou, X Li, Q Yang - Cancers, 2022 - mdpi.com
Simple Summary Ovarian cancer is the gynaecologic malignant tumour with the highest
mortality. Most patients are already in the advanced stage when they are found, and the 5 …