FTO in cancer: functions, molecular mechanisms, and therapeutic implications
N 6-methyladenosine (m 6 A) is the most abundant internal modification in mRNA that
affects RNA processing, stability, and translation. Discovered as the first RNA m 6 A …
affects RNA processing, stability, and translation. Discovered as the first RNA m 6 A …
Methylation across the central dogma in health and diseases: new therapeutic strategies
R Liu, E Zhao, H Yu, C Yuan, MN Abbas… - Signal Transduction and …, 2023 - nature.com
The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …
Melatonin: regulation of biomolecular condensates in neurodegenerative disorders
Biomolecular condensates are membraneless organelles (MLOs) that form dynamic,
chemically distinct subcellular compartments organizing macromolecules such as proteins …
chemically distinct subcellular compartments organizing macromolecules such as proteins …
Oncogenic and tumor-suppressive functions of the RNA demethylase FTO
HR Zuidhof, CF Calkhoven - Cancer Research, 2022 - AACR
The epitranscriptome represents the more than 140 types of chemically varying and
reversable RNA modifications affecting RNA fate. Among these, the most relevant for this …
reversable RNA modifications affecting RNA fate. Among these, the most relevant for this …
m6A‐Dependent Modulation via IGF2BP3/MCM5/Notch Axis Promotes Partial EMT and LUAD Metastasis
X Yang, Q Bai, W Chen, J Liang, F Wang… - Advanced …, 2023 - Wiley Online Library
The importance of mRNA N6‐methyladenosine (m6A) modification during tumor metastasis
is controversial as it plays distinct roles in different biological contexts. Moreover, how …
is controversial as it plays distinct roles in different biological contexts. Moreover, how …
Regulation of m6A modification on ferroptosis and its potential significance in radiosensitization
X Chen, L Zhang, Y He, S Huang, S Chen… - Cell Death …, 2023 - nature.com
Radiotherapy is often used to treat various types of cancers, but radioresistance greatly
limits the clinical efficiency. Recent studies have shown that radiotherapy can lead to …
limits the clinical efficiency. Recent studies have shown that radiotherapy can lead to …
Epitranscriptic regulation of HRAS by N6-methyladenosine drives tumor progression
Y Pan, Y Gu, T Liu, Q Zhang, F Yang… - Proceedings of the …, 2023 - National Acad Sciences
Overexpression of Ras, in addition to the oncogenic mutations, occurs in various human
cancers. However, the mechanisms for epitranscriptic regulation of RAS in tumorigenesis …
cancers. However, the mechanisms for epitranscriptic regulation of RAS in tumorigenesis …
The multifaceted functions of the Fat mass and Obesity-associated protein (FTO) in normal and cancer cells
The last decade has seen mRNA modification emerge as a new layer of gene expression
regulation. The Fat mass and obesity-associated protein (FTO) was the first identified eraser …
regulation. The Fat mass and obesity-associated protein (FTO) was the first identified eraser …
[HTML][HTML] Nanomaterial-assisted CRISPR gene-engineering–A hallmark for triple-negative breast cancer therapeutics advancement
Triple-negative breast cancer (TNBC) is the most violent class of tumor and accounts for 20–
24% of total breast carcinoma, in which frequently rare mutation occurs in high frequency …
24% of total breast carcinoma, in which frequently rare mutation occurs in high frequency …
FTO inhibits epithelial ovarian cancer progression by destabilising SNAI1 mRNA through IGF2BP2
M Sun, X Zhang, F Bi, D Wang, X Zhou, X Li, Q Yang - Cancers, 2022 - mdpi.com
Simple Summary Ovarian cancer is the gynaecologic malignant tumour with the highest
mortality. Most patients are already in the advanced stage when they are found, and the 5 …
mortality. Most patients are already in the advanced stage when they are found, and the 5 …