Diffusion and Flux Improvement of Drugs through Complexation

MKC Mannava, A Garai, AK Nangia - Molecular Pharmaceutics, 2023 - ACS Publications
Improving the solubility and permeability of drugs via cocrystallization is an important theme
in crystal engineering with practical applications for the discovery and development of high …

Structural Characterization of Pharmaceutical Cocrystals with the Use of Laboratory X-ray Powder Diffraction Patterns

VV Chernyshev - Crystals, 2023 - mdpi.com
X-ray powder diffraction is a vital analytical tool that is used in pharmaceutical science. It is
increasingly used to establish the crystal structure of a new pharmaceutical substance, in …

Mechanosynthesis of Stable Salt Hydrates of Allopurinol with Enhanced Dissolution, Diffusion, and Pharmacokinetics

RB Varsa S, N Pandey, A Ghosh, A Srivastava… - ACS …, 2023 - ACS Publications
Allopurinol (ALO) is a medication that treats gout and kidney stones by lowering uric acid
synthesis in the blood. The biopharmaceutics classification system (BCS) IV drug exhibits …

Cocrystallization-driven double-optimized stratagem toward directional self-assembly for the first ternary salt cocrystal of cardiotonic drug milrinone with different …

SS Meng, YM Yu, FZ Bu, CW Yan, ZY Wu… - Molecular …, 2023 - ACS Publications
The current research leverages the structural features and property superiorities along with
benefits in protecting cardiovascular system of gallic acid (GLC) and gentisic acid (HGA) to …

Synthetic Strategies toward Higher Cocrystals of Some Resorcinols

S Roy, R Gaur, M Paul, M Rajkumar… - Crystal Growth & …, 2022 - ACS Publications
Higher cocrystal synthesis depends on precise strategic approaches. A total of 32
stoichiometric ternary and quaternary cocrystals based on resorcinol derivatives were …

Solubility Enhancement of the Nonsteroidal Anti-inflammatory Drug of Pelubiprofen Salts

S Allu, JH An, BJ Park, WS Kim - Crystal Growth & Design, 2023 - ACS Publications
Pelubiprofen (PBF) is an anti-inflammatory drug that effectively relieves pain in rheumatoid
patients compared to other BCS class II nonsteroidal anti-inflammatory drugs (NSAIDs). In …

Multicomponent Solvate Crystals of 3, 5-Dinitrobenzoic Acid and Acetamide and CSD Analysis of Solvates

TR Shaikh, N Shelke, S Tothadi - ACS omega, 2023 - ACS Publications
Twelve multicomponent solvate crystals (cocrystal solvates) of 3, 5-dinitrobenzoic acid and
acetamide were synthesized via slow evaporation method. All crystalline materials were …

Rational Design of the Carbamazepine Ternary Cocrystals

DE Boycov, KV Drozd, AN Manin… - Crystal Growth & …, 2024 - ACS Publications
The first ternary cocrystals of carbamazepine (CBZ) were successfully identified through a
large-scale screening. A design strategy involved the use of an aliphatic dicarboxylic acid to …

Uncovering Cocrystal Formation and Competition Mechanism of Polyhydroxy Natural Products: Cases of Quercetin, Hesperidin, Resveratrol, and Curcumin

D Li, W Chen, L Zhou, L Xu, F He, JYY Heng… - Crystal Growth & …, 2024 - ACS Publications
Understanding drug cocrystal formation and its competitive mechanism is important for
improving the physicochemical properties of drugs. In this article, the cocrystal formation of …

Exploring the Co-Crystallization Landscape of One-Dimensional Coordination Polymers Using a Molecular Electrostatic Potential-Driven Approach

O Mišura, I Kodrin, M Borovina, M Pisačić… - Crystal growth & …, 2023 - ACS Publications
The ability of coordination polymers (CPs) to form multicomponent heteromeric materials,
where the key structural features of the parent CP are retained, has been explored via …