Diffusion and Flux Improvement of Drugs through Complexation
Improving the solubility and permeability of drugs via cocrystallization is an important theme
in crystal engineering with practical applications for the discovery and development of high …
in crystal engineering with practical applications for the discovery and development of high …
Structural Characterization of Pharmaceutical Cocrystals with the Use of Laboratory X-ray Powder Diffraction Patterns
VV Chernyshev - Crystals, 2023 - mdpi.com
X-ray powder diffraction is a vital analytical tool that is used in pharmaceutical science. It is
increasingly used to establish the crystal structure of a new pharmaceutical substance, in …
increasingly used to establish the crystal structure of a new pharmaceutical substance, in …
Mechanosynthesis of Stable Salt Hydrates of Allopurinol with Enhanced Dissolution, Diffusion, and Pharmacokinetics
Allopurinol (ALO) is a medication that treats gout and kidney stones by lowering uric acid
synthesis in the blood. The biopharmaceutics classification system (BCS) IV drug exhibits …
synthesis in the blood. The biopharmaceutics classification system (BCS) IV drug exhibits …
Cocrystallization-driven double-optimized stratagem toward directional self-assembly for the first ternary salt cocrystal of cardiotonic drug milrinone with different …
SS Meng, YM Yu, FZ Bu, CW Yan, ZY Wu… - Molecular …, 2023 - ACS Publications
The current research leverages the structural features and property superiorities along with
benefits in protecting cardiovascular system of gallic acid (GLC) and gentisic acid (HGA) to …
benefits in protecting cardiovascular system of gallic acid (GLC) and gentisic acid (HGA) to …
Synthetic Strategies toward Higher Cocrystals of Some Resorcinols
Higher cocrystal synthesis depends on precise strategic approaches. A total of 32
stoichiometric ternary and quaternary cocrystals based on resorcinol derivatives were …
stoichiometric ternary and quaternary cocrystals based on resorcinol derivatives were …
Solubility Enhancement of the Nonsteroidal Anti-inflammatory Drug of Pelubiprofen Salts
Pelubiprofen (PBF) is an anti-inflammatory drug that effectively relieves pain in rheumatoid
patients compared to other BCS class II nonsteroidal anti-inflammatory drugs (NSAIDs). In …
patients compared to other BCS class II nonsteroidal anti-inflammatory drugs (NSAIDs). In …
Multicomponent Solvate Crystals of 3, 5-Dinitrobenzoic Acid and Acetamide and CSD Analysis of Solvates
Twelve multicomponent solvate crystals (cocrystal solvates) of 3, 5-dinitrobenzoic acid and
acetamide were synthesized via slow evaporation method. All crystalline materials were …
acetamide were synthesized via slow evaporation method. All crystalline materials were …
Rational Design of the Carbamazepine Ternary Cocrystals
DE Boycov, KV Drozd, AN Manin… - Crystal Growth & …, 2024 - ACS Publications
The first ternary cocrystals of carbamazepine (CBZ) were successfully identified through a
large-scale screening. A design strategy involved the use of an aliphatic dicarboxylic acid to …
large-scale screening. A design strategy involved the use of an aliphatic dicarboxylic acid to …
Uncovering Cocrystal Formation and Competition Mechanism of Polyhydroxy Natural Products: Cases of Quercetin, Hesperidin, Resveratrol, and Curcumin
D Li, W Chen, L Zhou, L Xu, F He, JYY Heng… - Crystal Growth & …, 2024 - ACS Publications
Understanding drug cocrystal formation and its competitive mechanism is important for
improving the physicochemical properties of drugs. In this article, the cocrystal formation of …
improving the physicochemical properties of drugs. In this article, the cocrystal formation of …
Exploring the Co-Crystallization Landscape of One-Dimensional Coordination Polymers Using a Molecular Electrostatic Potential-Driven Approach
The ability of coordination polymers (CPs) to form multicomponent heteromeric materials,
where the key structural features of the parent CP are retained, has been explored via …
where the key structural features of the parent CP are retained, has been explored via …