The mitogen-activated protein kinase (MAPK) signaling pathway is the primary regulatory
module of various cellular processes such as cell proliferation, differentiation, and stress …

Extracellular signal-regulated kinase 5 (ERK5) belongs to the mitogen-activated protein
kinase (MAPK) family that consists of highly conserved enzymes expressed in all eukaryotic …

Mitogen-activated protein kinases (MAPKs) regulate diverse cellular processes including
proliferation, cell survival, differentiation, and apoptosis. While conventional MAPK …

Simple Summary Alterations of the MEK5/ERK5 signaling pathway have been described in
several tumors, and emerging data are trying to explain the complexity of ERK5-related …

Breast cancer can reoccur, often as bone metastasis, many years if not decades after the
primary tumor has been treated. The factors that stimulate dormant metastases to grow are …

Hepatocellular carcinoma (HCC) is a common disease with a significant mortality, and there
is no effective treatment for advanced patients. Growing evidence indicates that circRNAs …

We have reported that the oncoprotein hepatitis B X-interacting protein (HBXIP) plays a
crucial role in the promotion of migration of breast cancer cells. Lamellipodia and filopodia …

Clear cell renal cell carcinoma (ccRCC) is a highly invasive urological malignant tumor that
results in shorter patient survival. At present, the mechanism of ccRCC metastasis is not …

Micropapillary features are seen in pure mucinous carcinoma of breast (PMC), which is
termed mucinous carcinoma with micropapillary features (MPMC). However, whether MPMC …

Renal cancer would greatly benefit from new therapeutic strategies since, in advanced
stages, it is refractory to classical chemotherapeutic approaches. In this context, lysosomal …