Astrocytes have been in the limelight of active research for about 3 decades now. Over this
period, ideas about their function and role in the nervous system have evolved from simple …

The pathological phenomena of seizures and spreading depression have long been
considered separate physiological events in the brain. By incorporating conservation of …

Recent studies have shown that seizures can spread and terminate across brain areas via a
rich diversity of spatiotemporal patterns. In particular, while the location of the seizure onset …

The biophysical mechanisms underlying epileptogenesis and the generation of seizures
remain to be better understood. Among many factors triggering epileptogenesis are …

Cortical activity depends upon a continuous supply of oxygen and other metabolic
resources. Perinatal disruption of oxygen availability is a common clinical scenario in …

Cell volume changes are ubiquitous in normal and pathological activity of the brain.
Nevertheless, we know little of how cell volume affects neuronal dynamics. We here …

Resting-or baseline-state low-frequency (0.01–0.2 Hz) brain activity is observed in fMRI,
EEG, and local field potential recordings. These fluctuations were found to be correlated …

Measurements of neuronal signals during human seizure activity and evoked epileptic
activity in experimental models suggest that, in these pathological states, the individual …

Epileptic seizure dynamics span multiple scales in space and time. Understanding seizure
mechanisms requires identifying the relations between seizure components within and …

Within the computational neuroscience community, there has been a focus on simulating the
electrical activity of neurons, while other components of brain tissue, such as glia cells and …