Getting personal with neoantigen-based therapeutic cancer vaccines
N Hacohen, EF Fritsch, TA Carter, ES Lander… - Cancer immunology …, 2013 - AACR
Despite years of preclinical efforts and hundreds of clinical studies, therapeutic cancer
vaccines with the routine ability to limit or eliminate tumor growth in humans have been …
vaccines with the routine ability to limit or eliminate tumor growth in humans have been …
ERAP1 structure, function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases
C Alvarez-Navarro, JAL de Castro - Molecular immunology, 2014 - Elsevier
The endoplasmic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme involved
in the final processing of Major Histocompatibility Complex class I (MHC-I) ligands and with …
in the final processing of Major Histocompatibility Complex class I (MHC-I) ligands and with …
A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques
Background None of the HIV T-cell vaccine candidates that have reached advanced clinical
testing have been able to induce protective T cell immunity. A major reason for these failures …
testing have been able to induce protective T cell immunity. A major reason for these failures …
HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes
We investigated the hypothesis that the correlation between the class I HLA types of an
individual and whether that individual spontaneously controls HIV-1 is mediated by the …
individual and whether that individual spontaneously controls HIV-1 is mediated by the …
A conserved HIV-1-derived peptide presented by HLA-E renders infected T-cells highly susceptible to attack by NKG2A/CD94-bearing natural killer cells
ZB Davis, A Cogswell, H Scott, A Mertsching… - PLoS …, 2016 - journals.plos.org
Major histocompatibility class I (MHC-I)-specific inhibitory receptors on natural killer (NK)
cells (iNKRs) tolerize mature NK cell responses toward normal cells. NK cells generate …
cells (iNKRs) tolerize mature NK cell responses toward normal cells. NK cells generate …
Improved immune responses against Zika virus after sequential dengue and Zika virus infection in humans
The high levels of dengue-virus (DENV) seroprevalence in areas where the Zika virus (ZIKV)
is circulating and the cross-reactivity between these two viruses have raised concerns on the …
is circulating and the cross-reactivity between these two viruses have raised concerns on the …
HIV-1 p24gag Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice
Viral diversity is considered a major impediment to the development of an effective HIV-1
vaccine. Despite this diversity, certain protein segments are nearly invariant across the …
vaccine. Despite this diversity, certain protein segments are nearly invariant across the …
CD8+ TCR bias and immunodominance in HIV-1 infection
HN Kløverpris, R McGregor, JE McLaren… - The Journal of …, 2015 - journals.aai.org
Immunodominance describes a phenomenon whereby the immune system consistently
targets only a fraction of the available Ag pool derived from a given pathogen. In the case of …
targets only a fraction of the available Ag pool derived from a given pathogen. In the case of …
Therapeutic conserved elements (CE) DNA vaccine induces strong T-cell responses against highly conserved viral sequences during simian-human …
P Munson, Y Liu, D Bratt, JT Fuller, X Hu… - Human Vaccines & …, 2018 - Taylor & Francis
ABSTRACT HIV-specific T-cell responses play a key role in controlling HIV infection, and
therapeutic vaccines for HIV that aim to improve viral control will likely need to improve on …
therapeutic vaccines for HIV that aim to improve viral control will likely need to improve on …
Variable processing and cross-presentation of HIV by dendritic cells and macrophages shapes CTL immunodominance and immune escape
J Dinter, E Duong, NY Lai, MJ Berberich… - PLoS …, 2015 - journals.plos.org
Dendritic cells (DCs) and macrophages (Møs) internalize and process exogenous HIV-
derived antigens for cross-presentation by MHC-I to cytotoxic CD8+ T cells (CTL). However …
derived antigens for cross-presentation by MHC-I to cytotoxic CD8+ T cells (CTL). However …