[HTML][HTML] Polycythemia vera: historical oversights, diagnostic details, and therapeutic views

A Tefferi, AM Vannucchi, T Barbui - Leukemia, 2021 - nature.com
Polycythemia vera (PV) is a relatively indolent myeloid neoplasm with median survival that
exceeds 35 years in young patients, but its natural history might be interrupted by …

Appropriate management of polycythaemia vera with cytoreductive drug therapy: European LeukemiaNet 2021 recommendations

M Marchetti, AM Vannucchi, M Griesshammer… - The Lancet …, 2022 - thelancet.com
Polycythaemia vera is associated with a reduced quality of life, a high rate of vascular
events, and an intrinsic risk of disease evolution. The results of several randomised trials for …

Genetic basis and molecular profiling in myeloproliferative neoplasms

D Luque Paz, R Kralovics, RC Skoda - Blood, 2023 - ashpublications.org
Abstract BCR:: ABL1-negative myeloproliferative neoplasms (MPNs) are clonal diseases
originating from a single hematopoietic stem cell that cause excessive production of mature …

Ropeginterferon alfa-2b versus phlebotomy in low-risk patients with polycythaemia vera (Low-PV study): a multicentre, randomised phase 2 trial

T Barbui, AM Vannucchi, V De Stefano… - The Lancet …, 2021 - thelancet.com
Background There is no evidence that phlebotomy alone is sufficient to steadily maintain
haematocrit on target level in low-risk patients with polycythaemia vera. This study aimed to …

[HTML][HTML] High mortality rate in COVID-19 patients with myeloproliferative neoplasms after abrupt withdrawal of ruxolitinib

T Barbui, AM Vannucchi, A Alvarez-Larran, A Iurlo… - Leukemia, 2021 - nature.com
We report the clinical presentation and risk factors for survival in 175 patients with
myeloproliferative neoplasms (MPN) and COVID-19, diagnosed between February and …

Long-term efficacy and safety of ruxolitinib versus best available therapy in polycythaemia vera (RESPONSE): 5-year follow up of a phase 3 study

JJ Kiladjian, P Zachee, M Hino, F Pane… - The Lancet …, 2020 - thelancet.com
Background Polycythaemia vera is a myeloproliferative neoplasm characterised by
excessive proliferation of erythroid, myeloid, and megakaryocytic components in the bone …

Life after ruxolitinib: reasons for discontinuation, impact of disease phase, and outcomes in 218 patients with myelofibrosis

F Palandri, M Breccia, M Bonifacio, N Polverelli… - Cancer, 2020 - Wiley Online Library
Background After discontinuing ruxolitinib, the outcome of patients with myelofibrosis
reportedly has been poor. The authors investigated whether disease characteristics before …

Leukocytosis and thrombosis in essential thrombocythemia and polycythemia vera: a systematic review and meta-analysis

A Carobbio, A Ferrari, A Masciulli, A Ghirardi… - Blood …, 2019 - ashpublications.org
In the last years, a growing amount of evidence has been produced regarding the role of
leukocytosis as a risk factor for thrombosis in patients with myeloproliferative neoplasms …

Interferon-alpha for treating polycythemia vera yields improved myelofibrosis-free and overall survival

G Abu-Zeinah, S Krichevsky, T Cruz, G Hoberman… - Leukemia, 2021 - nature.com
Interferon-alpha (rIFNα) is the only disease-modifying treatment for polycythemia vera (PV),
but whether or not it prolongs survival is unknown. This large single center retrospective …

Ropeginterferon versus standard therapy for low-risk patients with polycythemia vera

T Barbui, AM Vannucchi, V De Stefano… - NEJM …, 2023 - evidence.nejm.org
Background Whether phlebotomy alone can adequately maintain target hematocrit in
patients with low-risk polycythemia vera (PV) remains elusive. Methods In a phase 2 open …