Physical stimuli are essential for the function of eukaryotic cells, and changes in physical
signals are important elements in normal tissue development as well as in disease initiation …

The extracellular matrix is perturbed in tumors. The tumor matrix promotes the growth,
survival, and invasion of the cancer and modifies fibroblast and immune cell behavior to …

Tissues stiffen during aging and during the pathological progression of cancer, fibrosis, and
cardiovascular disease. Extracellular matrix stiffness is emerging as a prominent mechanical …

YAP/TAZ is a master regulator of mechanotransduction whose functions rely on
translocation from the cytoplasm to the nucleus in response to diverse physical cues …

Mechanical cues in the cell microenvironment such as those from extracellular matrix
properties, stretching, compression and shear stress, play a critical role in maintaining …

Future research that will define the endothelial contribution to stiffness-related
cardiovascular disease may provide new targets for intervention to restore endothelial …

The interplay between mechanical stimuli and cellular mechanobiology orchestrates the
physiology of tissues and organs in a dynamic balance characterized by constant …

In vivo, cells of the vascular system are subjected to various mechanical stimuli and have
demonstrated the ability to adapt their behavior via mechanotransduction. Recent advances …

Aims Arterial stiffness is an underlying risk factor and a hallmark of cardiovascular diseases.
The endothelial cell (EC) glycocalyx is a glycan rich surface layer that plays a key role in …

Vascular endothelial growth factor (VEGF) can mediate endothelial cell migration,
proliferation, and angiogenesis. During cancer progression, VEGF production is often …