Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

Cell migration is essential for many biological processes, while abnormal cell migration is
characteristic of cancer cells. Epithelial cells become motile by undergoing epithelial-to …

Cell migration is crucial for cancer dissemination. We find that AMP-activated protein kinase
(AMPK) controls cell migration by acting as an adhesion sensing molecular hub. In 3 …

ROCK belongs to the AGC family of Ser/Thr protein kinases that are involved in many
cellular processes. ROCK-driven actomyosin contractility regulates cytoskeletal dynamics …

Small extracellular vesicles (sEVs) such as exosomes are nanoscale membranous particles
(< 200 nm) that have emerged as crucial targets for liquid biopsy and as promising drug …

Metastasis involves dissemination of cancer cells away from a primary tumour and
colonization at distal sites. During this process, the mechanical properties of the nucleus …

Pancreatic ductal adenocarcinoma (PDAC) has a very poor prognosis because of its high
propensity to metastasize and its immunosuppressive microenvironment. Using a panel of …

Dishevelled-associated activator of morphogenesis 1 (DAAM1) is a critical driver in
facilitating metastasis in breast cancer (BrCa). However, molecular mechanisms for the …

Wnt ligands are secreted signaling proteins that display a wide range of biological effects.
They play key roles in stimulating Wnt signaling pathways to facilitate processes such as …