Recent advances in the mechanisms of lung alveolarization and the pathogenesis of bronchopulmonary dysplasia
DMG Silva, C Nardiello, A Pozarska… - American Journal of …, 2015 - journals.physiology.org
Alveolarization is the process by which the alveoli, the principal gas exchange units of the
lung, are formed. Along with the maturation of the pulmonary vasculature, alveolarization is …
lung, are formed. Along with the maturation of the pulmonary vasculature, alveolarization is …
Endothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling
Pulmonary endothelial progenitor cells (EPCs) are critical for neonatal lung angiogenesis
and represent a subset of general capillary cells (gCAPs). Molecular mechanisms through …
and represent a subset of general capillary cells (gCAPs). Molecular mechanisms through …
Therapeutic potential of endothelial progenitor cells in pulmonary diseases
OA Kolesnichenko, JA Whitsett, TV Kalin… - American Journal of …, 2021 - atsjournals.org
Compromised alveolar development and pulmonary vascular remodeling are hallmarks of
pediatric lung diseases such as bronchopulmonary dysplasia (BPD) and alveolar capillary …
pediatric lung diseases such as bronchopulmonary dysplasia (BPD) and alveolar capillary …
Pathogenetics of alveolar capillary dysplasia with misalignment of pulmonary veins
Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a lethal
lung developmental disorder caused by heterozygous point mutations or genomic deletion …
lung developmental disorder caused by heterozygous point mutations or genomic deletion …
Postnatal Alveologenesis Depends on FOXF1 Signaling in c-KIT+ Endothelial Progenitor Cells
Rationale: Disruption of alveologenesis is associated with severe pediatric lung disorders,
including bronchopulmonary dysplasia (BPD). Although c-KIT+ endothelial cell (EC) …
including bronchopulmonary dysplasia (BPD). Although c-KIT+ endothelial cell (EC) …
Single cell multiomics identifies cells and genetic networks underlying alveolar capillary dysplasia
M Guo, KA Wikenheiser-Brokamp… - American journal of …, 2023 - atsjournals.org
Rationale: Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a
lethal developmental disorder of lung morphogenesis caused by insufficiency of FOXF1 …
lethal developmental disorder of lung morphogenesis caused by insufficiency of FOXF1 …
Generation of pulmonary endothelial progenitor cells for cell-based therapy using interspecies mouse–rat chimeras
Rationale: Although pulmonary endothelial progenitor cells (EPCs) hold promise for cell-
based therapies for neonatal pulmonary disorders, whether EPCs can be derived from …
based therapies for neonatal pulmonary disorders, whether EPCs can be derived from …
The S52F FOXF1 mutation inhibits STAT3 signaling and causes alveolar capillary dysplasia
A Pradhan, A Dunn, V Ustiyan, C Bolte… - American journal of …, 2019 - atsjournals.org
Rationale: Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a
lethal congenital disorder causing respiratory failure and pulmonary hypertension shortly …
lethal congenital disorder causing respiratory failure and pulmonary hypertension shortly …
Novel FOXF1-stabilizing compound tanfe stimulates lung angiogenesis in alveolar capillary dysplasia
Rationale: Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is
linked to heterozygous mutations in the FOXF1 (Forkhead Box F1) gene, a key …
linked to heterozygous mutations in the FOXF1 (Forkhead Box F1) gene, a key …
[HTML][HTML] FOXF1 transcription factor promotes lung morphogenesis by inducing cellular proliferation in fetal lung mesenchyme
V Ustiyan, C Bolte, Y Zhang, L Han, Y Xu… - Developmental …, 2018 - Elsevier
Organogenesis is regulated by mesenchymal-epithelial signaling events that induce
expression of cell-type specific transcription factors critical for cellular proliferation …
expression of cell-type specific transcription factors critical for cellular proliferation …