Recent advances in the mechanisms of lung alveolarization and the pathogenesis of bronchopulmonary dysplasia

DMG Silva, C Nardiello, A Pozarska… - American Journal of …, 2015 - journals.physiology.org
Alveolarization is the process by which the alveoli, the principal gas exchange units of the
lung, are formed. Along with the maturation of the pulmonary vasculature, alveolarization is …

Endothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling

G Wang, B Wen, Z Deng, Y Zhang… - Nature …, 2022 - nature.com
Pulmonary endothelial progenitor cells (EPCs) are critical for neonatal lung angiogenesis
and represent a subset of general capillary cells (gCAPs). Molecular mechanisms through …

Therapeutic potential of endothelial progenitor cells in pulmonary diseases

OA Kolesnichenko, JA Whitsett, TV Kalin… - American Journal of …, 2021 - atsjournals.org
Compromised alveolar development and pulmonary vascular remodeling are hallmarks of
pediatric lung diseases such as bronchopulmonary dysplasia (BPD) and alveolar capillary …

Pathogenetics of alveolar capillary dysplasia with misalignment of pulmonary veins

P Szafranski, T Gambin, AV Dharmadhikari… - Human genetics, 2016 - Springer
Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a lethal
lung developmental disorder caused by heterozygous point mutations or genomic deletion …

Postnatal Alveologenesis Depends on FOXF1 Signaling in c-KIT+ Endothelial Progenitor Cells

X Ren, V Ustiyan, M Guo, G Wang, C Bolte… - American journal of …, 2019 - atsjournals.org
Rationale: Disruption of alveologenesis is associated with severe pediatric lung disorders,
including bronchopulmonary dysplasia (BPD). Although c-KIT+ endothelial cell (EC) …

Single cell multiomics identifies cells and genetic networks underlying alveolar capillary dysplasia

M Guo, KA Wikenheiser-Brokamp… - American journal of …, 2023 - atsjournals.org
Rationale: Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a
lethal developmental disorder of lung morphogenesis caused by insufficiency of FOXF1 …

Generation of pulmonary endothelial progenitor cells for cell-based therapy using interspecies mouse–rat chimeras

G Wang, B Wen, X Ren, E Li, Y Zhang… - American journal of …, 2021 - atsjournals.org
Rationale: Although pulmonary endothelial progenitor cells (EPCs) hold promise for cell-
based therapies for neonatal pulmonary disorders, whether EPCs can be derived from …

The S52F FOXF1 mutation inhibits STAT3 signaling and causes alveolar capillary dysplasia

A Pradhan, A Dunn, V Ustiyan, C Bolte… - American journal of …, 2019 - atsjournals.org
Rationale: Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a
lethal congenital disorder causing respiratory failure and pulmonary hypertension shortly …

Novel FOXF1-stabilizing compound tanfe stimulates lung angiogenesis in alveolar capillary dysplasia

A Pradhan, L Che, V Ustiyan, AA Reza… - American journal of …, 2023 - atsjournals.org
Rationale: Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is
linked to heterozygous mutations in the FOXF1 (Forkhead Box F1) gene, a key …

[HTML][HTML] FOXF1 transcription factor promotes lung morphogenesis by inducing cellular proliferation in fetal lung mesenchyme

V Ustiyan, C Bolte, Y Zhang, L Han, Y Xu… - Developmental …, 2018 - Elsevier
Organogenesis is regulated by mesenchymal-epithelial signaling events that induce
expression of cell-type specific transcription factors critical for cellular proliferation …