Applications of amyloid, tau, and neuroinflammation PET imaging to Alzheimer's disease and mild cognitive impairment
Alzheimer's disease (AD) is a devastating and progressive neurodegenerative disease for
which there is no cure. Mild cognitive impairment (MCI) is considered a prodromal stage of …
which there is no cure. Mild cognitive impairment (MCI) is considered a prodromal stage of …
Imaging of reactive astrogliosis by positron emission tomography
R Harada, S Furumoto, Y Kudo, K Yanai… - Frontiers in …, 2022 - frontiersin.org
Many neurodegenerative diseases are neuropathologically characterized by neuronal loss,
gliosis, and the deposition of misfolded proteins such as β-amyloid (Aβ) plaques and tau …
gliosis, and the deposition of misfolded proteins such as β-amyloid (Aβ) plaques and tau …
Discriminative binding of tau PET tracers PI2620, MK6240 and RO948 in Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy brains
ML Malarte, PG Gillberg, A Kumar, N Bogdanovic… - Molecular …, 2023 - nature.com
Recent mechanistic and structural studies have challenged the classical tauopathy
classification approach and revealed the complexity and heterogeneity of tau pathology in …
classification approach and revealed the complexity and heterogeneity of tau pathology in …
Single-domain antibody–based noninvasive in vivo imaging of α-synuclein or tau pathology
Intracellular deposition of α-synuclein and tau are hallmarks of synucleinopathies and
tauopathies, respectively. Recently, several dye-based imaging probes with selectivity for …
tauopathies, respectively. Recently, several dye-based imaging probes with selectivity for …
[HTML][HTML] Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative …
AM Chaney, FR Lopez-Picon, S Serrière, R Wang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Mouse models of Alzheimer's disease (AD) are valuable but do not fully recapitulate human
AD pathology, such as spontaneous Tau fibril accumulation and neuronal loss …
AD pathology, such as spontaneous Tau fibril accumulation and neuronal loss …
Amyloid and tau positron emission tomography imaging in Alzheimer's disease and other tauopathies
The detection and staging of Alzheimer's disease (AD) using non-invasive imaging
biomarkers is of substantial clinical importance. Positron emission tomography (PET) …
biomarkers is of substantial clinical importance. Positron emission tomography (PET) …
[HTML][HTML] Tau aggregation and increased neuroinflammation in athletes after sports-related concussions and in traumatic brain injury patients–A PET/MR study
Traumatic brain injury (TBI) and repeated sports-related concussions (rSRCs) are
associated with an increased risk for neurodegeneration. Autopsy findings of selected …
associated with an increased risk for neurodegeneration. Autopsy findings of selected …
Overview of tau PET molecular imaging
GC Petersen, M Roytman, GC Chiang… - Current opinion in …, 2022 - journals.lww.com
Overview of tau PET molecular imaging : Current Opinion in Neurology Overview of tau PET
molecular imaging : Current Opinion in Neurology Log in or Register Subscribe to journalSubscribe …
molecular imaging : Current Opinion in Neurology Log in or Register Subscribe to journalSubscribe …
The sensitivity of tau tracers for the discrimination of Alzheimer's disease patients and healthy controls by PET
Z Mohammadi, H Alizadeh, J Marton, P Cumming - Biomolecules, 2023 - mdpi.com
Hyperphosphorylated tau aggregates, also known as neurofibrillary tangles, are a hallmark
neuropathological feature of Alzheimer's disease (AD). Molecular imaging of tau by positron …
neuropathological feature of Alzheimer's disease (AD). Molecular imaging of tau by positron …
Clinical validity of second-generation tau PET tracers as biomarkers for Alzheimer's disease in the context of a structured 5-phase development framework
Abstract Purpose In 2017, the Geneva Alzheimer's disease (AD) strategic biomarker
roadmap initiative proposed a framework of the systematic validation AD biomarkers to …
roadmap initiative proposed a framework of the systematic validation AD biomarkers to …