Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ)
have both emerged as important drivers of cancer progression and metastasis. YAP and …

There has been an increase in incidence reports of rare imprinting disorders associated with
assisted reproductive technology (ART). ART, including in vitro fertilization and …

Lung cancer is a major cause of death in the United States and other countries. The risk of
lung cancer is greatly increased by cigarette smoking and by certain occupational …

BACKGROUND: There is an increased incidence of rare imprinting disorders associated
with assisted reproduction technologies (ARTs). The sex-specific epigenetic modifications …

Downregulation of the LATS1 tumour suppressor protein kinase contributes to tumour
formation in mammals and flies. Strikingly, the tumour suppressor activity depends on the …

Genetic analysis of solid tumours using DNA or cDNA expression microarrays may enable
individualized treatment based on the profiles of genetic changes that are identified from …

The kinase LATS/WARTS is a tumor suppressor protein conserved in evolution, but its
function at the molecular level is not well understood. We report here that human LATS1 …

Background The putative tumor suppressor WWOX gene spans the common chromosomal
fragile site 16D (FRA16D) at chromosome area 16q23. 3-24.1. This region is a frequent …

The NDR (nuclear Dbf2-related)/LATS (large tumour suppressor) family of kinases
represents a subclass of the AGC (protein kinase A (PKA)/PKG/PKC-like) group of …

The acquisition of a mesenchymal phenotype is a critical step in the metastatic progression
of epithelial carcinomas. Adherens junctions (AJs) are required for suppressing this …