Forty years since the structural elucidation of platelet-activating factor (PAF): historical, current, and future research perspectives
In the late 1960s, Barbaro and Zvaifler described a substance that caused antigen induced
histamine release from rabbit platelets producing antibodies in passive cutaneous …
histamine release from rabbit platelets producing antibodies in passive cutaneous …
Recent advances in biological activities of rhodium complexes: Their applications in drug discovery research
Unique structure, characteristic reactivity, and facile synthesis of metal complexes have
made them efficient ligands in drug development research. Among them, rhodium …
made them efficient ligands in drug development research. Among them, rhodium …
Re (I) tricarbonyl complex of 1, 10-phenanthroline-5, 6-dione: DNA binding, cytotoxicity, anti-inflammatory and anti-coagulant effects towards platelet activating factor
M Kaplanis, G Stamatakis, VD Papakonstantinou… - Journal of inorganic …, 2014 - Elsevier
The complex fac-[Re (CO) 3 (phendione) Cl](1)(where phendione= 1, 10-phenanthroline-5,
6-dione) has been synthesized and fully characterized by UV–visible, FTIR, and NMR …
6-dione) has been synthesized and fully characterized by UV–visible, FTIR, and NMR …
α-Hederin inhibits the platelet activating factor-induced metastasis of HCC cells through disruption of PAF/PTAFR axis cascaded STAT3/MMP-2 expression
L Cao, Y Zhang, J Mi, Z Shi, Z Fang, D Jia, Z Pan… - Pharmacological …, 2022 - Elsevier
Metastasis remains a crucial obstacle to the clinical treatment of hepatocellular carcinoma
(HCC). Investigating the potential anti-tumor compounds from medicinal herb against HCC …
(HCC). Investigating the potential anti-tumor compounds from medicinal herb against HCC …
[HTML][HTML] The role of platelet-activating factor in chronic inflammation, immune activation, and comorbidities associated with HIV infection
T Kelesidis, V Papakonstantinou, P Detopoulou… - AIDS …, 2015 - ncbi.nlm.nih.gov
With the advent of highly effective antiretroviral therapy, cardiovascular disease has become
an important cause of morbidity and mortality among people with treated HIV-1, but the …
an important cause of morbidity and mortality among people with treated HIV-1, but the …
The interaction of rhodium compounds with proteins: A structural overview
Rhodium compounds have been used as scaffold for enzyme inhibitors, modulators of
protein/protein interactions and of protein aggregation. These compounds have been …
protein/protein interactions and of protein aggregation. These compounds have been …
[HTML][HTML] The potential role of dietary platelet-activating factor inhibitors in cancer prevention and treatment
Cancer is the second leading cause of mortality worldwide. The role of unresolved
inflammation in cancer progression and metastasis is well established. Platelet-activating …
inflammation in cancer progression and metastasis is well established. Platelet-activating …
[HTML][HTML] Platelet aggregometry assay for evaluating the effects of platelet agonists and antiplatelet compounds on platelet function in vitro
Platelet aggregometry assays are generally used for the analysis of platelet function but can
also be adapted for further research and therapy focused applications. This method …
also be adapted for further research and therapy focused applications. This method …
A review on platelet activating factor inhibitors: could a new class of potent metal‐based anti‐inflammatory drugs induce anticancer properties?
VD Papakonstantinou, N Lagopati… - Bioinorganic …, 2017 - Wiley Online Library
In this minireview, we refer to recent results as far as the Platelet Activating Factor (PAF)
inhibitors are concerned. At first, results of organic compounds (natural and synthetic ones …
inhibitors are concerned. At first, results of organic compounds (natural and synthetic ones …
Metabolomics analysis and modeling suggest a lysophosphocholines-PAF receptor interaction in fibromyalgia
Fibromyalgia Syndrome (FMS) is a chronic disease characterized by widespread pain, and
difficult to diagnose and treat. We analyzed the plasma metabolic profile of patients with …
difficult to diagnose and treat. We analyzed the plasma metabolic profile of patients with …