The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …

Endothelial cells transduce the frictional force from blood flow (fluid shear stress) into
biochemical signals that regulate gene expression and cell behavior via specialized …

CD36 is a broadly expressed membrane glycoprotein that acts as a facilitator of fatty acid
uptake, a signaling molecule, and a receptor for a wide range of ligands, including apoptotic …

Plaque angiogenesis, IPH, and inflammation contribute to plaque vulnerability.
Histopathologic and imaging studies together with specific experimental studies have …

Peripheral arterial disease (PAD) is a common vascular disease that reduces blood flow
capacity to the legs of patients. PAD leads to exercise intolerance that can progress in …

Mouse hind limb ischemia is the most common used preclinical model for peripheral arterial
disease and critical limb ischemia. This model is used to investigate the mechanisms of …

Impaired endothelial cell (EC)–mediated angiogenesis contributes to critical limb ischemia
in diabetic patients. The sonic hedgehog (SHH) pathway participates in angiogenesis but is …

Collateral artery growth is a potent natural defence mechanism to prevent death and
myocardial infarction in occlusive artery disease. Given the high prevalence of arterial …

A small amount of adipose tissue associated with small arteries and arterioles is
encountered both in mice and man. This perivascular adipose tissue (PVAT) has a paracrine …

Fibronectin in the vascular wall promotes inflammatory activation of the endothelium during
vascular remodeling and atherosclerosis. These effects are mediated in part by fibronectin …