Stem cells (SCs) hold great promise for cell therapy, tissue engineering, and regenerative
medicine as well as pharmaceutical and biotechnological applications. They have the …

Technical progress in materials science and bioprinting has for the past few decades
fostered considerable advances in medicine. More recently, the understanding of the …

Microfluidic systems provide an interesting alternative to standard macroscale cell cultures
due to the decrease in the number of cells and reagents as well as the improved physiology …

The approaches for maintaining hepatocytes in vitro are aimed at recapitulating aspects of
the native liver microenvironment through the use of co-cultures, surface coatings and 3D …

Drug development is often a very long, costly, and risky process due to the lack of reliability
in the preclinical studies. Traditional current preclinical models, mostly based on 2D cell …

Human induced pluripotent stem cells (hiPSCs) can serve as an unlimited source to rebuild
organotypic tissues in vitro. Successful engineering of functional cell types and complex …

Human pluripotent stem cells (hPSCs) represent an excellent cell source for regenerative
medicine and tissue engineering applications. However, there remains a need for robust …

Precision cancer medicine seeks to target the underlying genetic alterations of cancer;
however, it has been challenging to use genetic profiles of individual patients in identifying …

At diagnosis, over 70% of bladder cancers (BC) are at the non-muscle-invasive bladder
cancer (NMIBC) stages which are usually treated with transurethral resection followed by …

Human stem cell-derived cells and tissues hold considerable potential for applications in
regenerative medicine, disease modeling and drug discovery. The generation, culture and …