Depression is a syndrome of stress-and emotion-dysregulation, involving compromised
structural integrity of frontal-limbic networks. Meta-analytic evidence indicates that volumetric …

Chronic stressful life events are risk factors for developing major depression, the
pathophysiology of which is strongly linked to impairments in serotonin (5-HT) …

Earlier observations in neuroscience suggested that no new neurons form in the mature
central nervous system. Evidence now indicates that new neurons do form in the adult …

The dentate gyrus (DG), in addition to its role in learning and memory, is increasingly
implicated in the pathophysiology of anxiety disorders. Here, we show that, dependent on …

The gabapentinoids, gabapentin, and pregabalin, target the α2δ subunits of voltage-gated
calcium channels. Initially licensed for pain and seizures, they have become widely …

Cognitive dysfunction is a symptomatic domain identified across many mental disorders.
Cognitive deficits in individuals with major depressive disorder (MDD) contribute …

Depression and dementia are major public health problems. Major depressive disorder
(MDD) and Alzheimer's disease (AD) reciprocally elevate the risk for one another. No …

The signaling pathway of the microtubule-associated protein kinase or extracellular
regulated kinase (MAPK/ERK) is a common mechanism of extracellular information …

High-fat diet (HFD) consumption is generally associated with an increased risk of cognitive
and emotional dysfunctions that constitute a sizeable worldwide health burden with …

Psychiatric disorders continue to be among the most challenging disorders to diagnose and
treat because there is no single genetic or anatomical locus that is causative for the disease …