The circadian clock, a highly specialized, hierarchical network of biological pacemakers,
directs and maintains proper rhythms in endocrine and metabolic pathways required for …

Metabolomics is the comprehensive assessment of endogenous metabolites and attempts to
systematically identify and quantify metabolites from a biological sample. Small-molecule …

The intestinal microbiota undergoes diurnal compositional and functional oscillations that
affect metabolic homeostasis, but the mechanisms by which the rhythmic microbiota …

Sleep restriction and circadian clock disruption are associated with metabolic disorders such
as obesity, insulin resistance, and diabetes. The metabolic pathways involved in human …

Circadian rhythms occur in almost all species and control vital aspects of our physiology,
from sleeping and waking to neurotransmitter secretion and cellular metabolism …

Mitochondrial fission-fusion dynamics and mitochondrial bioenergetics, including oxidative
phosphorylation and generation of ATP, are strongly clock controlled. Here we show that …

Autophagy has emerged as a critical lysosomal pathway that maintains cell function and
survival through the degradation of cellular components such as organelles and proteins …

The circadian clock orchestrates many aspects of human physiology, and disruption of this
clock has been implicated in various pathologies, ranging from cancer to metabolic …

The choice of sample-preparation method is extremely important in metabolomic studies
because it affects both the observed metabolite content and biological interpretation of the …

Circadian clocks play a major role in orchestrating daily physiology, and their disruption can
evoke metabolic diseases such as fatty liver and obesity. To study the role of circadian …