Organismal ageing is accompanied by progressive loss of cellular function and systemic
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …

Aging is typified by a progressive decline in mitochondrial activity and stress resilience.
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …

Mitochondria were first postulated to contribute to aging more than 40 years ago. During the
following decades, multiple lines of evidence in model organisms and humans showed that …

BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

The ovarian system comprises vital organs in females and is of great significance for the
maintenance of reproductive potential and endocrine stability. Although complex …

Animal mitochondrial DNA (mtDNA) is commonly described as a small, circular molecule
that is conserved in size, gene content, and organization. Data collected in the last decade …

Background The accumulation of mitochondrial DNA (mtDNA) mutations, and the reduction
of mtDNA copy number, both disrupt mitochondrial energetics, and may contribute to aging …

Aging is a major risk factor for developing cancer, suggesting that these two events may
represent two sides of the same coin. It is becoming clear that some mechanisms involved in …

Mitochondrial DNA (mtDNA) depletion is involved in mtDNA depletion syndromes,
mitochondrial diseases, aging and aging-associated chronic diseases, and other human …

Mitochondrial dysfunction and impairment of the ubiquitin proteasome system have been
described as two hallmarks of the ageing process. Additionally, both systems have been …