The paper discusses general problems in using PEG for conjugation to high or low
molecular weight molecules. Methods of binding PEG to different functional groups in …

Polyethylene glycol (PEG) is widely used as a covalent modifier of biological
macromolecules and particulates as well as a carrier for low molecular weight drugs. In the …

One of the best biocompatible polymers, poly (ethylene glycol)(PEG),* 1 possesses an array
of useful properties (1, 2). Among them are a wide range of solubilities in both organic …

Polymer− drug conjugates (polymer therapeutics) are finding increasing use as novel
anticancer agents. Here a series of poly (ethylene glycol) PEG− doxorubicin (Dox) …

Procedures are described for linking monomethoxypoly (ethylene glycol)(mPEG) to both e
and a amino groups of lysine. The lysine carboxyl group can then be activated as a …

Monomethoxypolyethylene glycol (mPEG) of average molecular weight 5000 was
transformed in a series of synthetic steps to a new activated form of PEG, a stable thiol …

Pretargeting techniques using the avidin-biotin system have shown encouraging results in
both diagnostic and therapeutic clinical trials. It has been shown that in cancer therapy the …

Uricase from Bacillus fastidiosus (UC) was covalently linked to linear PEG (PEG-1)(Mw 5
kDa), branched PEG (PEG-2)(Mw 10 kDa) and to poly (N-acryloylmorpholine)(PAcM)(Mw 6 …

2008-08-19 Assigned to AMBRX, INC. reassignment AMBRX, INC. ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: KRAYNOV, VADIM …

A comparative pharmacokinetic and biodistribution investigation of polymer− protein
conjugates prepared with various amphiphilic polymers was carried out using uricase as a …