Synthesis of quinones with highlighted biological applications: A critical update on the strategies towards bioactive compounds with emphasis on lapachones
EN da Silva Júnior, GAM Jardim, C Jacob… - European Journal of …, 2019 - Elsevier
Naphthoquinones are of key importance in organic synthesis and medicinal chemistry. In the
last few years, various synthetic routes have been developed to prepare bioactive …
last few years, various synthetic routes have been developed to prepare bioactive …
Advanced Therapies for Ventricular Arrhythmias in Patients With Chagasic Cardiomyopathy: JACC State-of-the-Art Review
Chagas disease is caused by infection from the protozoan parasite Trypanosoma cruzi.
Although it is endemic to Latin America, global migration has led to an increased incidence …
Although it is endemic to Latin America, global migration has led to an increased incidence …
Resveratrol and curcumin for Chagas disease treatment—a systematic review
Chagas disease (CD) is a neglected protozoan infection caused by Trypanosoma cruzi,
which affects about 7 million people worldwide. There are two available drugs in …
which affects about 7 million people worldwide. There are two available drugs in …
The state of the art of extracellular vesicle research in protozoan infection
X Wang, J Chen, J Zheng - Frontiers in Genetics, 2022 - frontiersin.org
Protozoan diseases seriously affect the health of human beings, livestock and poultry and
lead to high economic and medical costs. Extracellular vesicles (EVs) are membranous …
lead to high economic and medical costs. Extracellular vesicles (EVs) are membranous …
Comprehensive analysis of miRNA–mRNA regulatory network and potential drugs in chronic chagasic cardiomyopathy across human and mouse
J Wu, J Cao, Y Fan, C Li, X Hu - BMC medical genomics, 2021 - Springer
Background Chronic chagasic cardiomyopathy (CCC) is the leading cause of heart failure in
Latin America and often causes severe inflammation and fibrosis in the heart. Studies on …
Latin America and often causes severe inflammation and fibrosis in the heart. Studies on …
Metabolic control analysis of the transsulfuration pathway and the compensatory role of the cysteine transport in Trypanosoma cruzi
C Vázquez, R Encalada, J Belmont-Díaz, M Rivera… - Biosystems, 2023 - Elsevier
Trypanosoma cruzi is the causal agent of American Trypanosomiasis or Chagas Disease in
humans. The current drugs for its treatment benznidazole and nifurtimox have …
humans. The current drugs for its treatment benznidazole and nifurtimox have …
Selenium, TGF-beta and infectious endemic cardiopathy: lessons from benchwork to clinical application in Chagas disease
TC Araujo-Jorge, MT Rivera, J Vanderpas, LR Garzoni… - Biomolecules, 2022 - mdpi.com
For over 60 years, selenium (Se) has been known as an essential microelement to many
biological functions, including cardiovascular homeostasis. This review presents a …
biological functions, including cardiovascular homeostasis. This review presents a …
Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2020: positron emission tomography, computed tomography, and magnetic resonance
WA AlJaroudi, FG Hage - Journal of Nuclear Cardiology, 2021 - Elsevier
Although the year 2020 was different from other years in many respects, the Journal of
Nuclear Cardiology published excellent articles pertaining to imaging in patients with …
Nuclear Cardiology published excellent articles pertaining to imaging in patients with …
Chagas heart disease: beyond a single complication, from asymptomatic disease to heart failure
IG Montalvo-Ocotoxtle, G Rojas-Velasco… - Journal of Clinical …, 2022 - mdpi.com
Chagas cardiomyopathy (CC), caused by the protozoan Trypanosoma cruzi, is an important
cause of cardiovascular morbidity and mortality in developing countries. It is estimated that 6 …
cause of cardiovascular morbidity and mortality in developing countries. It is estimated that 6 …
The Role of the Na+/Ca2+ Exchanger in Aberrant Intracellular Ca2+ in Cardiomyocytes of Chagas-Infected Rodents
Chagas disease is produced by the parasite Trypanosoma cruzi (T. cruzi), which is the
leading cause of death and morbidity in Latin America. We have shown that in patients with …
leading cause of death and morbidity in Latin America. We have shown that in patients with …